ENSG00000119408


Homo sapiens

Features
Gene ID: ENSG00000119408
  
Biological name :NEK6
  
Synonyms : NEK6 / NIMA related kinase 6 / Q9HC98
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q33.3
Gene start: 124257606
Gene end: 124353307
  
Corresponding Affymetrix probe sets: 223158_s_at (Human Genome U133 Plus 2.0 Array)   223159_s_at (Human Genome U133 Plus 2.0 Array)   223561_at (Human Genome U133 Plus 2.0 Array)   239267_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441469
Ensembl peptide - ENSP00000441426
Ensembl peptide - ENSP00000442636
Ensembl peptide - ENSP00000319734
Ensembl peptide - ENSP00000362698
Ensembl peptide - ENSP00000362702
Ensembl peptide - ENSP00000362705
Ensembl peptide - ENSP00000377749
Ensembl peptide - ENSP00000389517
Ensembl peptide - ENSP00000399847
Ensembl peptide - ENSP00000403087
Ensembl peptide - ENSP00000403414
Ensembl peptide - ENSP00000405215
Ensembl peptide - ENSP00000411401
Ensembl peptide - ENSP00000439651
NCBI entrez gene - 10783     See in Manteia.
OMIM - 604884
RefSeq - NM_001166169
RefSeq - NM_001145001
RefSeq - NM_001166167
RefSeq - NM_001166168
RefSeq - NM_001166170
RefSeq - NM_001166171
RefSeq - NM_014397
RefSeq - XM_005251664
RefSeq - XM_006716936
RefSeq - XM_017014217
RefSeq Peptide - NP_001159640
RefSeq Peptide - NP_001159641
RefSeq Peptide - NP_001159642
RefSeq Peptide - NP_001159643
RefSeq Peptide - NP_055212
RefSeq Peptide - NP_001138473
RefSeq Peptide - NP_001159639
swissprot - Q5TBG4
swissprot - Q5TBG7
swissprot - Q5TBH0
swissprot - A0A024R8A6
swissprot - Q5TBH1
swissprot - Q5TBH2
swissprot - Q9HC98
swissprot - Q5TBG1
swissprot - Q5TBG2
Ensembl - ENSG00000119408
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek6ENSDARG00000037963Danio rerio
 ENSGALG00000003979Gallus gallus
 Nek6ENSMUSG00000026749Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEK7 / Q8TDX7 / NIMA related kinase 7ENSG0000015141469
NEK2 / P51955 / NIMA related kinase 2ENSG0000011765029
NEK3 / P51956 / NIMA related kinase 3ENSG0000013609829
NEK9 / Q8TD19 / NIMA related kinase 9ENSG0000011963829
NEK4 / P51957 / NIMA related kinase 4ENSG0000011490428
NEK1 / Q96PY6 / NIMA related kinase 1ENSG0000013760128
NEK11 / Q8NG66 / NIMA related kinase 11ENSG0000011467027
NEK5 / Q6P3R8 / NIMA related kinase 5ENSG0000019716827
NEK8 / Q86SG6 / NIMA related kinase 8ENSG0000016060227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007077 mitotic nuclear envelope disassembly TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051225 spindle assembly TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:2000772 regulation of cellular senescence TAS
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0001222 transcription corepressor binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019894 kinesin binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000119638 NEK9 / Q8TD19 / NIMA related kinase 9  / complex / reaction






 

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