ENSMUSG00000026749


Mus musculus

Features
Gene ID: ENSMUSG00000026749
  
Biological name :Nek6
  
Synonyms : Nek6 / Q9ES70 / Serine/threonine-protein kinase Nek6
  
Possible biological names infered from orthology : NIMA related kinase 6 / Q9HC98
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 38511643
Gene end: 38594606
  
Corresponding Affymetrix probe sets: 10471844 (MoGene1.0st)   1423596_at (Mouse Genome 430 2.0 Array)   1425850_a_at (Mouse Genome 430 2.0 Array)   1451043_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108516
Ensembl peptide - ENSMUSP00000120294
Ensembl peptide - ENSMUSP00000114376
Ensembl peptide - ENSMUSP00000108523
Ensembl peptide - ENSMUSP00000049723
NCBI entrez gene - 59126     See in Manteia.
MGI - MGI:1891638
RefSeq - XM_006498210
RefSeq - NM_001159631
RefSeq - NM_021606
RefSeq - XM_006498209
RefSeq Peptide - NP_001153103
RefSeq Peptide - NP_067619
swissprot - A2ATP1
swissprot - A2ATN9
swissprot - A2ATP0
swissprot - Q9ES70
Ensembl - ENSMUSG00000026749
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek6ENSDARG00000037963Danio rerio
 ENSGALG00000003979Gallus gallus
 NEK6ENSG00000119408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek7 / Q9ES74 / Serine/threonine-protein kinase Nek7 / Q8TDX7* / NIMA related kinase 7*ENSMUSG0000002639375
Nek3 / Q9R0A5 / Serine/threonine-protein kinase Nek3 / P51956* / NIMA related kinase 3*ENSMUSG0000003147834
Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*ENSMUSG0000002662233
Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*ENSMUSG0000003429032
Nek4 / NIMA related kinase 4 / P51957*ENSMUSG0000002191831
Nek8 / Q91ZR4 / Serine/threonine-protein kinase Nek8 / Q86SG6* / NIMA related kinase 8*ENSMUSG0000001740531
Nek1 / P51954 / NIMA (never in mitosis gene a)-related expressed kinase 1 / Q96PY6* / NIMA related kinase 1*ENSMUSG0000003164431
Nek5 / Q7TSC3 / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA. / Q6P3R8* / NIMA related kinase 5*ENSMUSG0000003773829
Nek11 / Q8C0Q4 / Serine/threonine-protein kinase Nek11 / Q8NG66* / NIMA related kinase 11*ENSMUSG0000003503227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition ISS
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0001222 transcription corepressor binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019894 kinesin binding ISO
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tg(TcraTcrb)425Cbn/0,Trim30atm1Yjk/Trim30atm1Yjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034290 Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*  / complex / reaction






 

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