ENSMUSG00000021918


Mus musculus

Features
Gene ID: ENSMUSG00000021918
  
Biological name :Nek4
  
Synonyms : Nek4 / NIMA related kinase 4
  
Possible biological names infered from orthology : P51957
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 30951377
Gene end: 30988821
  
Corresponding Affymetrix probe sets: 10413640 (MoGene1.0st)   1427639_a_at (Mouse Genome 430 2.0 Array)   1449861_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154090
Ensembl peptide - ENSMUSP00000153710
Ensembl peptide - ENSMUSP00000154606
Ensembl peptide - ENSMUSP00000154678
Ensembl peptide - ENSMUSP00000057915
NCBI entrez gene - 23955     See in Manteia.
MGI - MGI:1344404
RefSeq - XM_011245069
RefSeq - NM_001308328
RefSeq - NM_011849
RefSeq - XM_011245068
RefSeq Peptide - NP_001295257
RefSeq Peptide - NP_035979
swissprot - Q3THY0
swissprot - Q3UED6
swissprot - Q6GTE9
Ensembl - ENSMUSG00000021918
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek4ENSDARG00000040152Danio rerio
 NEK4ENSGALG00000041428Gallus gallus
 NEK4ENSG00000114904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek1 / P51954 / NIMA (never in mitosis gene a)-related expressed kinase 1 / Q96PY6* / NIMA related kinase 1*ENSMUSG0000003164426
Nek11 / Q8C0Q4 / Serine/threonine-protein kinase Nek11 / Q8NG66* / NIMA related kinase 11*ENSMUSG0000003503220
Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*ENSMUSG0000003429020
Nek8 / Q91ZR4 / Serine/threonine-protein kinase Nek8 / Q86SG6* / NIMA related kinase 8*ENSMUSG0000001740517
Nek3 / Q9R0A5 / Serine/threonine-protein kinase Nek3 / P51956* / NIMA related kinase 3*ENSMUSG0000003147817
Nek5 / Q7TSC3 / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA. / Q6P3R8* / NIMA related kinase 5*ENSMUSG0000003773817
Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*ENSMUSG0000002662217
Nek7 / Q9ES74 / Serine/threonine-protein kinase Nek7 / Q8TDX7* / NIMA related kinase 7*ENSMUSG0000002639313
Nek6 / Q9ES70 / Serine/threonine-protein kinase Nek6 / Q9HC98* / NIMA related kinase 6*ENSMUSG0000002674912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:1900062 regulation of replicative cell aging IMP
 biological_processGO:2000772 regulation of cellular senescence IMP
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0035253 ciliary rootlet IDA
 cellular_componentGO:0035869 ciliary transition zone IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0097014 ciliary plasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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