ENSMUSG00000026622


Mus musculus

Features
Gene ID: ENSMUSG00000026622
  
Biological name :Nek2
  
Synonyms : Nek2 / O35942 / Serine/threonine-protein kinase Nek2
  
Possible biological names infered from orthology : NIMA related kinase 2 / P51955
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H6
Gene start: 191821444
Gene end: 191833050
  
Corresponding Affymetrix probe sets: 10352767 (MoGene1.0st)   1417299_at (Mouse Genome 430 2.0 Array)   1437579_at (Mouse Genome 430 2.0 Array)   1437580_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027931
NCBI entrez gene - 18005     See in Manteia.
MGI - MGI:109359
RefSeq - NM_010892
RefSeq - XM_006497123
RefSeq Peptide - NP_035022
swissprot - O35942
Ensembl - ENSMUSG00000026622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek2ENSDARG00000005619Danio rerio
 NEK2ENSGALG00000009854Gallus gallus
 NEK2ENSG00000117650Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek3 / Q9R0A5 / Serine/threonine-protein kinase Nek3 / P51956* / NIMA related kinase 3*ENSMUSG0000003147831
Nek1 / P51954 / NIMA (never in mitosis gene a)-related expressed kinase 1 / Q96PY6* / NIMA related kinase 1*ENSMUSG0000003164431
Nek4 / NIMA related kinase 4 / P51957*ENSMUSG0000002191830
Nek5 / Q7TSC3 / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA. / Q6P3R8* / NIMA related kinase 5*ENSMUSG0000003773829
Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*ENSMUSG0000003429028
Nek8 / Q91ZR4 / Serine/threonine-protein kinase Nek8 / Q86SG6* / NIMA related kinase 8*ENSMUSG0000001740527
Nek11 / Q8C0Q4 / Serine/threonine-protein kinase Nek11 / Q8NG66* / NIMA related kinase 11*ENSMUSG0000003503226
Nek6 / Q9ES70 / Serine/threonine-protein kinase Nek6 / Q9HC98* / NIMA related kinase 6*ENSMUSG0000002674923
Nek7 / Q9ES74 / Serine/threonine-protein kinase Nek7 / Q8TDX7* / NIMA related kinase 7*ENSMUSG0000002639323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IMP
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0046602 regulation of mitotic centrosome separation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051299 centrosome separation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0090307 mitotic spindle assembly IMP
 biological_processGO:1903126 negative regulation of centriole-centriole cohesion IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000922 spindle pole IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / complex / reaction
 ENSMUSG00000040084 Bub1b / Q9Z1S0 / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / reaction / complex
 ENSMUSG00000066979 Bub3 / Q9WVA3 / Mitotic checkpoint protein BUB3 / O43684* / BUB3, mitotic checkpoint protein*  / complex / reaction
 ENSMUSG00000029910 Mad2l1 / Q9Z1B5 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257* / mitotic arrest deficient 2 like 1*  / reaction / complex






 

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