ENSMUSG00000040084


Mus musculus

Features
Gene ID: ENSMUSG00000040084
  
Biological name :Bub1b
  
Synonyms : Bub1b / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / Q9Z1S0
  
Possible biological names infered from orthology : BUB1 mitotic checkpoint serine/threonine kinase B / O60566
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 118598211
Gene end: 118641591
  
Corresponding Affymetrix probe sets: 10474769 (MoGene1.0st)   1416961_at (Mouse Genome 430 2.0 Array)   1447362_at (Mouse Genome 430 2.0 Array)   1447363_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037126
NCBI entrez gene - 12236     See in Manteia.
MGI - MGI:1333889
RefSeq - NM_009773
RefSeq - XM_006498622
RefSeq Peptide - NP_033903
swissprot - Q9Z1S0
Ensembl - ENSMUSG00000040084
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bub1bbENSDARG00000074927Danio rerio
 BUB1BENSGALG00000036892Gallus gallus
 BUB1BENSG00000156970Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bub1 / mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2 / O43683* / BUB1 mitotic checkpoint serine/threonine kinase*ENSMUSG0000002737916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013212  Mad3/Bub1 homology region 1
 IPR015661  Mitotic spindle checkpoint protein Bub1/Mad3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007091 metaphase/anaphase transition of mitotic cell cycle IGI
 biological_processGO:0007094 mitotic spindle assembly checkpoint IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034501 protein localization to kinetochore IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051754 meiotic sister chromatid cohesion, centromeric IBA
 biological_processGO:0071459 protein localization to chromosome, centromeric region IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore ISO
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IDA
 cellular_componentGO:0000940 condensed chromosome outer kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IBA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm1.1Jvd/Bub1b+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Bub1btm1.1Hsl/Bub1b+,Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm1Jvd/Bub1b+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Bub1btm1.1Jvd/Bub1b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Bub1btm1.1Hsl/Bub1b+,Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008007 abnormal cellular replicative senescence "anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [GO:0001302, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0009315 rectum adenocarcinoma "malignant neoplasm of epithelial cells in the rectum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Bub1btm1.1Hsl/Bub1b+,Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Samhd1tm2.2Crs/Samhd1tm2.2Crs
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Bub1btm2.1Jvd/Bub1b+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Bub1btm1.1Hsl/Bub1b+
Genetic Background: involves: 129 * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Slc14a1tm1Ask/Slc14a1tm1Ask
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / complex / reaction
 ENSMUSG00000026622 Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*  / complex / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction / complex
 ENSMUSG00000066979 Bub3 / Q9WVA3 / Mitotic checkpoint protein BUB3 / O43684* / BUB3, mitotic checkpoint protein*  / reaction / complex
 ENSMUSG00000029910 Mad2l1 / Q9Z1B5 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257* / mitotic arrest deficient 2 like 1*  / complex / reaction






 

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