ENSMUSG00000066979


Mus musculus

Features
Gene ID: ENSMUSG00000066979
  
Biological name :Bub3
  
Synonyms : Bub3 / Mitotic checkpoint protein BUB3 / Q9WVA3
  
Possible biological names infered from orthology : BUB3, mitotic checkpoint protein / O43684
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 131560222
Gene end: 131571895
  
Corresponding Affymetrix probe sets: 10558248 (MoGene1.0st)   1416815_s_at (Mouse Genome 430 2.0 Array)   1448058_s_at (Mouse Genome 430 2.0 Array)   1448473_at (Mouse Genome 430 2.0 Array)   1459104_at (Mouse Genome 430 2.0 Array)   1459918_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081547
Ensembl peptide - ENSMUSP00000147045
Ensembl peptide - ENSMUSP00000146881
Ensembl peptide - ENSMUSP00000146670
Ensembl peptide - ENSMUSP00000146334
NCBI entrez gene - 12237     See in Manteia.
MGI - MGI:1343463
RefSeq - XM_006507271
RefSeq - NM_001317350
RefSeq - NM_009774
RefSeq Peptide - NP_001304279
RefSeq Peptide - NP_033904
swissprot - A0A140LJ21
swissprot - A0A140LIM5
swissprot - A0A140LHA2
swissprot - A0A140LI47
swissprot - Q9WVA3
Ensembl - ENSMUSG00000066979
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bub3ENSDARG00000075883Danio rerio
 BUB3ENSGALG00000009681Gallus gallus
 BUB3ENSG00000154473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rae1 / Q8C570 / mRNA export factor / P78406* / ribonucleic acid export 1*ENSMUSG0000002750935


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0007094 mitotic spindle assembly checkpoint IBA
 biological_processGO:0008608 attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051983 regulation of chromosome segregation IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IBA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0033597 mitotic checkpoint complex IBA
 cellular_componentGO:1990298 bub1-bub3 complex IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

 MP:0008007 abnormal cellular replicative senescence "anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [GO:0001302, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bub3tm1Jvd/Bub3+,Rae1tm1Jvd/Rae1+
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cyp19a1tm1Toda/Cyp19a1tm1Toda
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bub3tm1Jvd/Bub3tm1Jvd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction / complex
 ENSMUSG00000029910 Mad2l1 / Q9Z1B5 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257* / mitotic arrest deficient 2 like 1*  / reaction / complex
 ENSMUSG00000026622 Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*  / complex / reaction
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / complex / reaction
 ENSMUSG00000040084 Bub1b / Q9Z1S0 / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr