ENSMUSG00000019942


Mus musculus

Features
Gene ID: ENSMUSG00000019942
  
Biological name :Cdk1
  
Synonyms : Cdk1 / Cyclin-dependent kinase 1 / P11440
  
Possible biological names infered from orthology : P06493
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B5.3
Gene start: 69335146
Gene end: 69352938
  
Corresponding Affymetrix probe sets: 10369815 (MoGene1.0st)   1448314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113184
Ensembl peptide - ENSMUSP00000119085
Ensembl peptide - ENSMUSP00000020099
NCBI entrez gene - 12534     See in Manteia.
MGI - MGI:88351
RefSeq - NM_007659
RefSeq Peptide - NP_031685
swissprot - D3Z2T9
swissprot - P11440
Ensembl - ENSMUSG00000019942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk1ENSDARG00000087554Danio rerio
 CDK1ENSGALG00000003085Gallus gallus
 CDK1ENSG00000170312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*ENSMUSG0000002535864
Cdk3-ps / cyclin dependent kinase 3 / CDK3* / Q00526*ENSMUSG0000009230062
Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*ENSMUSG0000002896956
Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*ENSMUSG0000004027445
Cdk11b / P24788 / Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript variant 3, mRNA. / Q9UQ88* / CDK11A* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B*ENSMUSG0000002906242
Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*ENSMUSG0000000672842
Cdk10 / Q3UMM4 / Cyclin-dependent kinase 10 / Q15131*ENSMUSG0000003386241
E030030I06RikENSMUSG0000009732713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IBA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IDA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034501 protein localization to kinetochore ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0044772 mitotic cell cycle phase transition IMP
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051445 regulation of meiotic cell cycle IBA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0090166 Golgi disassembly ISS
 biological_processGO:1900182 positive regulation of protein localization to nucleus ISO
 biological_processGO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport ISO
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0072686 mitotic spindle IBA
 cellular_componentGO:0097125 cyclin B1-CDK1 complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISO
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030332 cyclin binding ISO
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0035173 histone kinase activity ISO
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity ISO


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1tm1(Cdk2)Kald
Genetic Background: Not Specified

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnn2bc-6J/Kcnn2bc-6J
Genetic Background: C57BL/6J-Kcnn2bc-6J/GrsrJ

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Kcnn2bc-6J/Kcnn2bc-6J
Genetic Background: C57BL/6J-Kcnn2bc-6J/GrsrJ

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0003706 abnormal nucleus count "absent or greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis or events leading to apoptosis" [pg:Philip Groth submission]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnn2bc-6J/Kcnn2bc-6J
Genetic Background: C57BL/6J-Kcnn2bc-6J/GrsrJ

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdk1tm2.1Kald/Cdk1tm2.1Kald,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA * SJL

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Nr4a2tm1Niko/Nr4a2tm1Niko
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk1Gt(P009F08)Bbd/Cdk1Gt(P009F08)Bbd
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1tm1(Cdk2)Kald
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdk1Gt(P009F08)Bbd/Cdk1Gt(P009F08)Bbd
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006398 Cdc20 / Q9JJ66 / Cell division cycle / Q12834* / cell division cycle 20*  / reaction / complex
 ENSMUSG00000041229 Phf8 / Q80TJ7 / Histone lysine demethylase PHF8 / Q9UPP1* / PHD finger protein 8*  / reaction
 ENSMUSG00000034021 Pds5b / Q4VA53 / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA. / Q9NTI5* / PDS5 cohesin associated factor B*  / reaction
 ENSMUSG00000028063 Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*  / reaction
 ENSMUSG00000019773 Fbxo5 / Q7TSG3 / F-box only protein 5 / Q9UKT4* / F-box protein 5*  / reaction
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / reaction
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / reaction
 ENSMUSG00000042688 Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*  / reaction
 ENSMUSG00000001517 Foxm1 / forkhead box M1 / Q08050*  / reaction
 ENSMUSG00000024791 Cdca5 / Q9CPY3 / Sororin / Q96FF9* / cell division cycle associated 5*  / reaction
 ENSMUSG00000020593 Lpin1 / Mus musculus lipin 1 (Lpin1), transcript variant 4, mRNA. / Q14693* / lipin 1*  / reaction
 ENSMUSG00000032218 Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*  / complex / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000041408 Wapl / Q65Z40 / WAPL cohesin release factor / Q7Z5K2*  / reaction
 ENSMUSG00000045210 Vcpip1 / valosin containing protein (p97)/p47 complex interacting protein 1 / Q96JH7* / valosin containing protein interacting protein 1*  / reaction
 ENSMUSG00000066306 Numa1 / E9Q7G0 / Nuclear mitotic apparatus protein 1 / Q14980*  / reaction
 ENSMUSG00000029202 Pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction
 ENSMUSG00000034290 Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*  / reaction
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / reaction
 ENSMUSG00000023908 Pkmyt1 / Q9ESG9 / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase / Q99640* / protein kinase, membrane associated tyrosine/threonine 1*  / reaction
 ENSMUSG00000021103 Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSMUSG00000021548 Ccnh / Q61458 / Cyclin-H / P51946*  / reaction
 ENSMUSG00000027330 Cdc25b / P30306 / M-phase inducer phosphatase 2 / P30305* / cell division cycle 25B*  / reaction
 ENSMUSG00000031016 Wee1 / P47810 / WEE 1 homolog 1 (S. pombe) / P30291* / WEE1 G2 checkpoint kinase*  / reaction
 ENSMUSG00000040084 Bub1b / Q9Z1S0 / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / complex / reaction
 ENSMUSG00000047281 Sfn / O70456 / stratifin / P31947*  / reaction / complex
 ENSMUSG00000044201 Cdc25c / P48967 / cell division cycle 25C / P30307*  / reaction
 ENSMUSG00000066979 Bub3 / Q9WVA3 / Mitotic checkpoint protein BUB3 / O43684* / BUB3, mitotic checkpoint protein*  / reaction / complex
 ENSMUSG00000069089 Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*  / reaction
 ENSMUSG00000032477 Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*  / reaction
 ENSMUSG00000029910 Mad2l1 / Q9Z1B5 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257* / mitotic arrest deficient 2 like 1*  / reaction / complex






 

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contact: otassy@igbmc.fr