ENSMUSG00000028969


Mus musculus

Features
Gene ID: ENSMUSG00000028969
  
Biological name :Cdk5
  
Synonyms : Cdk5 / Cyclin-dependent-like kinase 5 / P49615
  
Possible biological names infered from orthology : cyclin dependent kinase 5 / Q00535
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 24418241
Gene end: 24423530
  
Corresponding Affymetrix probe sets: 10528583 (MoGene1.0st)   1422590_at (Mouse Genome 430 2.0 Array)   1450674_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030814
Ensembl peptide - ENSMUSP00000142413
NCBI entrez gene - 12568     See in Manteia.
MGI - MGI:101765
RefSeq - XM_006535626
RefSeq - NM_007668
RefSeq Peptide - NP_031694
swissprot - P49615
swissprot - Q543F6
swissprot - A0A0G2JDL3
Ensembl - ENSMUSG00000028969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk5ENSDARG00000056683Danio rerio
 CDK5ENSG00000164885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*ENSMUSG0000002535860
Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*ENSMUSG0000001994257
Cdk3-ps / cyclin dependent kinase 3 / CDK3* / Q00526*ENSMUSG0000009230057
Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*ENSMUSG0000004027446
Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*ENSMUSG0000000672845
Cdk10 / Q3UMM4 / Cyclin-dependent kinase 10 / Q15131*ENSMUSG0000003386243
Cdk11b / P24788 / Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript variant 3, mRNA. / Q9UQ88* / CDK11A* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B*ENSMUSG0000002906243
E030030I06RikENSMUSG0000009732713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006886 intracellular protein transport IMP
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0016310 phosphorylation ISO
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021695 cerebellar cortex development IMP
 biological_processGO:0021697 cerebellar cortex formation IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021819 layer formation in cerebral cortex IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030517 negative regulation of axon extension IGI
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031914 negative regulation of synaptic plasticity IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0032801 receptor catabolic process IMP
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0035418 protein localization to synapse IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0042501 serine phosphorylation of STAT protein IDA
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045055 regulated exocytosis IEA
 biological_processGO:0045786 negative regulation of cell cycle IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IMP
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IDA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus IMP
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 biological_processGO:0048489 synaptic vesicle transport IBA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IMP
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 biological_processGO:0070509 calcium ion import IMP
 biological_processGO:0090314 positive regulation of protein targeting to membrane IMP
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IMP
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016533 protein kinase 5 complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005176 ErbB-2 class receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016301 kinase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030549 acetylcholine receptor activator activity IDA
 molecular_functionGO:0043125 ErbB-3 class receptor binding IDA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IPI


Pathways (from Reactome)
Pathway description
DARPP-32 events
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdpk1tm2Ejm/Pdpk1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdpk1tm2Ejm/Pdpk1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Pdpk1tm2Ejm/Pdpk1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001956 hypopnea "breathing that is shallower and/or slower than normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64289]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdpk1tm2Ejm/Pdpk1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdk5tm2Kul/Cdk5tm2Kul,Tg(Nefh-cre)12Kul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002883 chromatolysis "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F11tm1Gjb/F11tm1Gjb
Genetic Background: B6.129X1-F11tm1Gjb

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex
 ENSMUSG00000040957 Q9ESJ1 / Cables1 / CDK5 and ABL1 enzyme substrate 1 / Q8TDN4* / Cdk5 and Abl enzyme substrate 1*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSMUSG00000028691 Prdx1 / P35700 / Peroxiredoxin-1 / Q06830*  / reaction
 ENSMUSG00000024590 Lmnb1 / P14733 / Lamin-B1 / P20700*  / reaction
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / complex
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / reaction
 ENSMUSG00000028063 Lmna / P48678 / Prelamin-A/C Lamin-A/C / P02545* / lamin A/C*  / reaction
 ENSMUSG00000005161 Prdx2 / Q61171 / Peroxiredoxin-2 / P32119*  / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex






 

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