ENSMUSG00000026640


Mus musculus

Features
Gene ID: ENSMUSG00000026640
  
Biological name :Plxna2
  
Synonyms : P70207 / Plexin-A2 / Plxna2
  
Possible biological names infered from orthology : O75051
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H6
Gene start: 194618218
Gene end: 194816869
  
Corresponding Affymetrix probe sets: 10352867 (MoGene1.0st)   1429772_at (Mouse Genome 430 2.0 Array)   1451753_at (Mouse Genome 430 2.0 Array)   1453286_at (Mouse Genome 430 2.0 Array)   1455037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027952
Ensembl peptide - ENSMUSP00000118087
NCBI entrez gene - 18845     See in Manteia.
MGI - MGI:107684
RefSeq - NM_008882
RefSeq - XM_006497240
RefSeq Peptide - NP_032908
swissprot - F6VSI0
swissprot - P70207
Ensembl - ENSMUSG00000026640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxna2ENSDARG00000060372Danio rerio
 PLXNA2ENSGALG00000001264Gallus gallus
 O75051ENSG00000076356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976567
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008463
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139859
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364634
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138533
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660631
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012330
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478522


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IEP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0021785 branchiomotor neuron axon guidance IBA
 biological_processGO:0021915 neural tube development IEP
 biological_processGO:0021935 cerebellar granule cell precursor tangential migration IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0060037 pharyngeal system development IEP
 biological_processGO:0060174 limb bud formation IEP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Celsr3tm1Agof/Celsr3tm2Agof,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Plxna4tm1Hfu/Plxna4tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6btm1Hfu/Sema6btm1Hfu
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6btm1Hfu/Sema6b+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2nmf454/Plxna2nmf454
Genetic Background: involves: C57BL/6J

Allelic Composition: Plxna2tm1Hfu/Plxna2+,Sema6aGt(KST069)Byg/Sema6a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plxna2nmf454/Plxna2nmf454
Genetic Background: involves: C57BL/6J

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Plxna2tm1Hfu/Plxna2tm1Hfu,Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000019647 O35464 / Sema6a / Semaphorin-6A / Q9H2E6*  / reaction / complex
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / reaction / complex
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex






 

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