ENSMUSG00000030084


Mus musculus

Features
Gene ID: ENSMUSG00000030084
  
Biological name :Plxna1
  
Synonyms : P70206 / Plexin-A1 / Plxna1
  
Possible biological names infered from orthology : Q9UIW2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 89316314
Gene end: 89362620
  
Corresponding Affymetrix probe sets: 10546184 (MoGene1.0st)   1421232_at (Mouse Genome 430 2.0 Array)   1428623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131840
Ensembl peptide - ENSMUSP00000145403
Ensembl peptide - ENSMUSP00000144822
Ensembl peptide - ENSMUSP00000063066
NCBI entrez gene - 18844     See in Manteia.
MGI - MGI:107685
RefSeq - NM_008881
RefSeq Peptide - NP_032907
swissprot - A0A0N4SW74
swissprot - A0A0N4SUU1
swissprot - P70206
Ensembl - ENSMUSG00000030084
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018148.1ENSDARG00000114823Danio rerio
 plxna1aENSDARG00000105452Danio rerio
 PLXNA1ENSGALG00000006097Gallus gallus
 PLXNA1ENSG00000114554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139866
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664063
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976563
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364635
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138533
B2RXS4 / Plxnb2 / plexin B2 / O15031*ENSMUSG0000003660632
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012332
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478521


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0014910 regulation of smooth muscle cell migration IMP
 biological_processGO:0021785 branchiomotor neuron axon guidance IBA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IDA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0097485 neuron projection guidance IMP
 biological_processGO:1990138 neuron projection extension IGI
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IPI


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pot1btm1.1Schg/Pot1btm1.1Schg
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Plxna1tm1Tmj/Plxna1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Plxna1tm1Kik/Plxna1tm1Kik
Genetic Background: Not Specified

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0003734 abnormal inner plexiform layer morphology "malformation/anomalous structure of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Pot1btm1.1Schg/Pot1btm1.1Schg
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Plxna1tm1Tmj/Plxna1tm1Tmj,Tg(Ntrk3-EGFP)BM45Gsat/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plxna1tm1Kik/Plxna1tm1Kik
Genetic Background: Not Specified

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Sema5atm1.2Alk/Sema5atm1.2Alk,Sema5btm1.2Alk/Sema5btm1.2Alk,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * CBA

 MP:0010197 abnormal lymphatic vessel endothelial cell morphology "any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / complex / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / complex
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000027200 Q76KF0 / Sema6d / Semaphorin-6D / Q8NFY4*  / complex / reaction
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction / complex
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / complex / reaction
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex
 ENSMUSG00000023992 Trem2 / Q99NH8 / Triggering receptor expressed on myeloid cells 2 / Q9NZC2*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / complex
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / reaction / complex






 

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