ENSMUSG00000036606


Mus musculus

Features
Gene ID: ENSMUSG00000036606
  
Biological name :Plxnb2
  
Synonyms : B2RXS4 / plexin B2 / Plxnb2
  
Possible biological names infered from orthology : O15031
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 89155549
Gene end: 89180788
  
Corresponding Affymetrix probe sets: 10431424 (MoGene1.0st)   1416683_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051731
Ensembl peptide - ENSMUSP00000104955
NCBI entrez gene - 140570     See in Manteia.
MGI - MGI:2154239
RefSeq - XM_011245451
RefSeq - NM_001159521
RefSeq - NM_001284506
RefSeq - NM_138749
RefSeq - XM_006520412
RefSeq - XM_006520413
RefSeq - XM_011245449
RefSeq - XM_011245450
RefSeq Peptide - NP_001152993
RefSeq Peptide - NP_001271435
RefSeq Peptide - NP_620088
swissprot - B2RXS4
Ensembl - ENSMUSG00000036606
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnb2aENSDARG00000003811Danio rerio
 plxnb2aENSDARG00000094799Danio rerio
 plxnb2bENSDARG00000036985Danio rerio
 si:ch211-127b11.1ENSDARG00000077090Danio rerio
 si:dkey-183c2.4ENSDARG00000079892Danio rerio
 PLXNB2ENSGALG00000039861Gallus gallus
 O15031ENSG00000196576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plxnb1 / Q8CJH3 / plexin B1 / O43157*ENSMUSG0000005364644
Plxnb3 / Q9QY40 / Plexin-B3 / Q9ULL4*ENSMUSG0000003138540
Plxnd1 / Q3UH93 / plexin D1 / Q9Y4D7*ENSMUSG0000003012333
P70206 / Plxna1 / Plexin-A1 / Q9UIW2*ENSMUSG0000003008433
P70207 / Plxna2 / Plexin-A2 / O75051*ENSMUSG0000002664032
Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*ENSMUSG0000002976532
P70208 / Plxna3 / plexin A3 / P51805*ENSMUSG0000003139831
Plxnc1 / Q9QZC2 / Plexin-C1 / O60486*ENSMUSG0000007478521


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISO
 biological_processGO:0007162 negative regulation of cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0050772 positive regulation of axonogenesis IGI
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:2001222 regulation of neuron migration IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: B6.129P2-Plxnb2tm1Matl

Allelic Composition: Plxnb2tm1a(EUCOMM)Wtsi/Plxnb2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Plxnb2tm1a(EUCOMM)Wtsi

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

Allelic Composition: Plxnb2tm1Matl/Plxnb2+,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

Allelic Composition: Plxnb2m597804Hubr/Plxnb2m597804Hubr
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001756 abnormal urination "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,KitW-v/KitW-v,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: B6.129P2-Plxnb2tm1Matl

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf10ptls/Fgf10ptls
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-NPM/ALK)N1Ingh/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * Swiss Webster

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Irf9M1Btlr/Irf9+
Genetic Background: C57BL/6J-Irf9M1Btlr

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0006097 abnormal cerebellar lobule formation "anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf9M1Btlr/Irf9+
Genetic Background: C57BL/6J-Irf9M1Btlr

Allelic Composition: Pax8tm1.1(cre)Mbu/Pax8+,Plxnb1tm1Rkun/Plxnb1tm1Rkun,Plxnb2tm1.1Rkun/Plxnb2tm1.1Rkun
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009941 abnormal olfactory bulb interneuron morphology "any structural anomaly of the group of neurons residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0009942 abnormal olfactory bulb granule cell morphology "any structural anomaly of the main intrinsic GABAergic neuron in the granule cell layer of the main olfactory bulb; dendrites of these cells receive synaptic input from mitral and tufted cell lateral dendrites in the external plexiform layer, and have synaptic outputs on those dendrites through reciprocal dendrodendritic synapses" [NLX:nifext_123 "NeuroLex.org"]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0009943 abnormal olfactory bulb periglomerular cell morphology "any structural anomaly of the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [NLX:nlx_cell_091202 "NeuroLex.org"]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0009950 abnormal olfactory bulb internal plexiform layer morphology 
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl,Sema4ctm1Matl/Sema4ctm1Matl
Genetic Background: B6.129P2-Sema4ctm1Matl Plxnb2tm1Matl

Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl,Sema4gtm1Kik/Sema4gtm1Kik
Genetic Background: B6.Cg-Plxnb2tm1Matl Sema4gtm1Kik

Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: B6.129P2-Plxnb2tm1Matl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Plxnb2tm1Rkun/Plxnb2tm1Rkun
Genetic Background: involves: FVB/N

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011760 abnormal ureteric bud tip morphology "any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [MGI:anna]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011761 abnormal ureteric bud trunk morphology "any structural anomaly of the ureteric bud cells that elongate to form a rigid structure (stalk) consisting of polarized epithelial cells without branching; the stalks differentiate into the collecting system of the mature kidney, while the tip cells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into nephrons" [MGI:anna]
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Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0011803 double kidney pelvis "duplication of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:anna]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012707 incomplete caudal neuropore closure "incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed" [MGI:anna]
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Allelic Composition: Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

Allelic Composition: Plxnb1tm1Matl/Plxnb1tm1Matl,Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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