ENSG00000196576


Homo sapiens

Features
Gene ID: ENSG00000196576
  
Biological name :PLXNB2
  
Synonyms : O15031 / plexin B2 / PLXNB2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.33
Gene start: 50274979
Gene end: 50307627
  
Corresponding Affymetrix probe sets: 208890_s_at (Human Genome U133 Plus 2.0 Array)   211472_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392620
Ensembl peptide - ENSP00000482999
Ensembl peptide - ENSP00000478347
Ensembl peptide - ENSP00000415757
Ensembl peptide - ENSP00000409171
Ensembl peptide - ENSP00000406048
Ensembl peptide - ENSP00000400679
Ensembl peptide - ENSP00000352288
Ensembl peptide - ENSP00000387470
NCBI entrez gene - 23654     See in Manteia.
OMIM - 604293
RefSeq - XM_017028704
RefSeq - XM_017028703
RefSeq - XM_011530682
RefSeq - XM_006724413
RefSeq - XM_005261911
RefSeq - XM_005261910
RefSeq - XM_005261909
RefSeq - NM_012401
RefSeq Peptide - NP_036533
swissprot - O15031
swissprot - E2PU09
swissprot - H0Y7X5
swissprot - H0Y6J7
swissprot - A0A087WU36
swissprot - A0A087X000
swissprot - A6QRG9
swissprot - A6QRH1
Ensembl - ENSG00000196576
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnb2aENSDARG00000003811Danio rerio
 plxnb2aENSDARG00000094799Danio rerio
 plxnb2bENSDARG00000036985Danio rerio
 si:ch211-127b11.1ENSDARG00000077090Danio rerio
 si:dkey-183c2.4ENSDARG00000079892Danio rerio
 PLXNB2ENSGALG00000039861Gallus gallus
 B2RXS4ENSMUSG00000036606Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43157 / PLXNB1 / plexin B1ENSG0000016405044
PLXNB3 / Q9ULL4 / plexin B3ENSG0000019875340
PLXND1 / Q9Y4D7 / plexin D1ENSG0000000439933
PLXNA1 / Q9UIW2 / plexin A1ENSG0000011455433
PLXNA4 / Q9HCM2 / plexin A4ENSG0000022186632
O75051 / PLXNA2 / plexin A2ENSG0000007635632
P51805 / PLXNA3 / plexin A3ENSG0000013082731
O60486 / PLXNC1 / plexin C1ENSG0000013604022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure ISS
 biological_processGO:0001932 regulation of protein phosphorylation ISS
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0007162 negative regulation of cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007405 neuroblast proliferation ISS
 biological_processGO:0007420 brain development ISS
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0050772 positive regulation of axonogenesis IBA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:2001222 regulation of neuron migration ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr