ENSG00000114554


Homo sapiens

Features
Gene ID: ENSG00000114554
  
Biological name :PLXNA1
  
Synonyms : plexin A1 / PLXNA1 / Q9UIW2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q21.3
Gene start: 126988594
Gene end: 127037392
  
Corresponding Affymetrix probe sets: 1558140_at (Human Genome U133 Plus 2.0 Array)   221537_at (Human Genome U133 Plus 2.0 Array)   221538_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377061
NCBI entrez gene - 5361     See in Manteia.
OMIM - 601055
RefSeq - XM_011512909
RefSeq - NM_032242
RefSeq - XM_011512908
RefSeq Peptide - NP_115618
swissprot - Q9UIW2
Ensembl - ENSG00000114554
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018148.1ENSDARG00000114823Danio rerio
 plxna1aENSDARG00000105452Danio rerio
 PLXNA1ENSGALG00000006097Gallus gallus
 P70206ENSMUSG00000030084Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51805 / PLXNA3 / plexin A3ENSG0000013082766
O75051 / PLXNA2 / plexin A2ENSG0000007635664
PLXNA4 / Q9HCM2 / plexin A4ENSG0000022186663
O43157 / PLXNB1 / plexin B1ENSG0000016405036
PLXNB3 / Q9ULL4 / plexin B3ENSG0000019875334
PLXND1 / Q9Y4D7 / plexin D1ENSG0000000439932
O15031 / PLXNB2 / plexin B2ENSG0000019657632
O60486 / PLXNC1 / plexin C1ENSG0000013604022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0014910 regulation of smooth muscle cell migration IEA
 biological_processGO:0021785 branchiomotor neuron axon guidance IBA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IBA
 biological_processGO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0097485 neuron projection guidance IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0002116 semaphorin receptor complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017154 semaphorin receptor activity TAS


Pathways (from Reactome)
Pathway description
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction / complex
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction
 ENSG00000006607 FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / complex / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction / complex
 ENSG00000182511 FES / P07332 / FES proto-oncogene, tyrosine kinase  / complex / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction / complex
 ENSG00000137872 Q8NFY4 / SEMA6D / semaphorin 6D  / reaction / complex
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000011600 O43914 / TYROBP / TYRO protein tyrosine kinase binding protein  / complex
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / complex
 ENSG00000095970 TREM2 / Q9NZC2 / triggering receptor expressed on myeloid cells 2  / complex






 

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