ENSG00000099250


Homo sapiens

Features
Gene ID: ENSG00000099250
  
Biological name :NRP1
  
Synonyms : neuropilin 1 / NRP1 / O14786
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.22
Gene start: 33177492
Gene end: 33336262
  
Corresponding Affymetrix probe sets: 1561365_at (Human Genome U133 Plus 2.0 Array)   210510_s_at (Human Genome U133 Plus 2.0 Array)   210615_at (Human Genome U133 Plus 2.0 Array)   212298_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000408911
Ensembl peptide - ENSP00000393071
Ensembl peptide - ENSP00000416147
Ensembl peptide - ENSP00000476896
Ensembl peptide - ENSP00000265371
Ensembl peptide - ENSP00000363949
Ensembl peptide - ENSP00000363954
Ensembl peptide - ENSP00000363955
Ensembl peptide - ENSP00000363956
Ensembl peptide - ENSP00000364001
Ensembl peptide - ENSP00000364009
Ensembl peptide - ENSP00000379317
Ensembl peptide - ENSP00000390447
Ensembl peptide - ENSP00000390567
NCBI entrez gene - 8829     See in Manteia.
OMIM - 602069
RefSeq - XM_017016866
RefSeq - NM_001024628
RefSeq - NM_001024629
RefSeq - NM_001244972
RefSeq - NM_001244973
RefSeq - NM_001330068
RefSeq - NM_003873
RefSeq - XM_006717521
RefSeq - XM_006717522
RefSeq - XM_006717523
RefSeq - XM_006717524
RefSeq - XM_006717525
RefSeq - XM_006717526
RefSeq - XM_011519755
RefSeq - XM_011519756
RefSeq - XM_017016865
RefSeq Peptide - NP_003864
RefSeq Peptide - NP_001019799
RefSeq Peptide - NP_001019800
RefSeq Peptide - NP_001231901
RefSeq Peptide - NP_001231902
RefSeq Peptide - NP_001316997
swissprot - Q5JWQ2
swissprot - Q5JWQ4
swissprot - Q5JWQ6
swissprot - Q5T7F0
swissprot - V9GYL7
swissprot - E7EX60
swissprot - O14786
swissprot - E9PEP6
swissprot - H0Y4A0
swissprot - H0Y4N6
swissprot - H0Y7Z2
Ensembl - ENSG00000099250
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrp1aENSDARG00000102153Danio rerio
 NRP1ENSGALG00000007140Gallus gallus
 Nrp1ENSMUSG00000025810Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRP2 / O60462 / neuropilin 2ENSG0000011825744
F8 / P00451 / coagulation factor VIIIENSG0000018501017
F5 / P12259 / coagulation factor VENSG0000019873417
EDIL3 / O43854 / EGF like repeats and discoidin domains 3ENSG0000016417614
DCBLD2 / Q96PD2 / discoidin, CUB and LCCL domain containing 2ENSG0000005701913
MFGE8 / Q08431 / milk fat globule-EGF factor 8 proteinENSG0000014054512
DCBLD1 / Q8N8Z6 / discoidin, CUB and LCCL domain containing 1ENSG0000016446510
HEPHL1 / Q6MZM0 / hephaestin like 1ENSG000001813338
HEPH / Q9BQS7 / hephaestinENSG000000894727
RS1 / O15537 / retinoschisin 1ENSG000001021046
CP / P00450 / ceruloplasminENSG000000474576


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027146  Neuropilin-1
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation TAS
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0003148 outflow tract septum morphogenesis ISS
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007413 axonal fasciculation IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration TAS
 biological_processGO:0014911 positive regulation of smooth muscle cell migration TAS
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021612 facial nerve structural organization IEA
 biological_processGO:0021636 trigeminal nerve morphogenesis IEA
 biological_processGO:0021637 trigeminal nerve structural organization IEA
 biological_processGO:0021649 vestibulocochlear nerve structural organization IEA
 biological_processGO:0021675 nerve development ISS
 biological_processGO:0021785 branchiomotor neuron axon guidance IEA
 biological_processGO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance ISS
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IMP
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISS
 biological_processGO:0036486 ventral trunk neural crest cell migration IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0038189 neuropilin signaling pathway IMP
 biological_processGO:0038190 VEGF-activated neuropilin signaling pathway ISS
 biological_processGO:0042327 positive regulation of phosphorylation IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IMP
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance ISS
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048844 artery morphogenesis ISS
 biological_processGO:0048846 axon extension involved in axon guidance ISS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050918 positive chemotaxis ISS
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0051894 positive regulation of focal adhesion assembly IDA
 biological_processGO:0060301 positive regulation of cytokine activity TAS
 biological_processGO:0060385 axonogenesis involved in innervation ISS
 biological_processGO:0060627 regulation of vesicle-mediated transport TAS
 biological_processGO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IEA
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis ISS
 biological_processGO:0060982 coronary artery morphogenesis IEA
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye ISS
 biological_processGO:0061441 renal artery morphogenesis IEA
 biological_processGO:0061549 sympathetic ganglion development ISS
 biological_processGO:0061551 trigeminal ganglion development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0071679 commissural neuron axon guidance ISS
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance ISS
 biological_processGO:0097102 endothelial tip cell fate specification ISS
 biological_processGO:0097374 sensory neuron axon guidance IEA
 biological_processGO:0097475 motor neuron migration ISS
 biological_processGO:0097490 sympathetic neuron projection extension ISS
 biological_processGO:0097491 sympathetic neuron projection guidance ISS
 biological_processGO:0150018 basal dendrite development ISS
 biological_processGO:0150020 basal dendrite arborization ISS
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development ISS
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IEA
 biological_processGO:1902336 positive regulation of retinal ganglion cell axon guidance ISS
 biological_processGO:1902378 VEGF-activated neuropilin signaling pathway involved in axon guidance IEA
 biological_processGO:1902946 protein localization to early endosome ISS
 biological_processGO:1903375 facioacoustic ganglion development IEA
 biological_processGO:1904835 dorsal root ganglion morphogenesis IEA
 biological_processGO:1905040 otic placode development IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0002116 semaphorin receptor complex NAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005769 early endosome ISS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005883 neurofilament IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle TAS
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043235 receptor complex TAS
 cellular_componentGO:0097443 sorting endosome ISS
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019955 cytokine binding NAS
 molecular_functionGO:0038085 vascular endothelial growth factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
Signaling by ROBO receptors
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Signal transduction by L1
CHL1 interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / reaction / complex
 ENSG00000006607 FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2  / complex / reaction
 ENSG00000134121 CHL1 / O00533 / cell adhesion molecule L1 like  / reaction / complex
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / complex / reaction
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / complex / reaction
 ENSG00000182511 FES / P07332 / FES proto-oncogene, tyrosine kinase  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000176749 CDK5R1 / Q15078 / cyclin dependent kinase 5 regulatory subunit 1  / complex / reaction
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / complex / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / complex / reaction
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction / complex
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex






 

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