ENSDARG00000102153


Danio rerio

Features
Gene ID: ENSDARG00000102153
  
Biological name :nrp1a
  
Synonyms : neuropilin 1a / nrp1a
  
Possible biological names infered from orthology : neuropilin 1 / NRP1 / O14786 / P97333
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 1162325
Gene end: 1356668
  
Corresponding Affymetrix probe sets: Dr.23740.1.A1_at (Zebrafish Array)   Dr.26440.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000141420
Ensembl peptide - ENSDARP00000153812
Ensembl peptide - ENSDARP00000148903
Ensembl peptide - ENSDARP00000134467
Ensembl peptide - ENSDARP00000140030
Ensembl peptide - ENSDARP00000140900
NCBI entrez gene - 353246     See in Manteia.
RefSeq - NM_181497
RefSeq - NM_001040326
RefSeq Peptide - NP_001035416
RefSeq Peptide - NP_852474
swissprot - A0A0R4IVS1
swissprot - A0A0R4IFP8
swissprot - F1QXE5
swissprot - Q1RLY9
ZFIN ID - ZDB-GENE-030519-2
Ensembl - ENSDARG00000102153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRP1ENSGALG00000007140Gallus gallus
 NRP1ENSG00000099250Homo sapiens
 Nrp1ENSMUSG00000025810Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nrp2a / neuropilin 2aENSDARG0000009654643
nrp2b / neuropilin 2bENSDARG0000003844643
nrp1b / neuropilin 1bENSDARG0000002729035
f5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*ENSDARG0000005570516
f8 / coagulation factor VIII, procoagulant component / P00451* / Q06194* / coagulation factor VIII*ENSDARG0000010138516
edil3b / EGF-like repeats and discoidin I-like domains 3b / EDIL3* / O35474* / O43854* / EGF like repeats and discoidin domains 3* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSDARG0000006087713
mfge8b / milk fat globule-EGF factor 8 protein bENSDARG0000004580313
mfge8a / milk fat globule-EGF factor 8 protein aENSDARG0000001534913
edil3a / EGF-like repeats and discoidin I-like domains 3a / EDIL3* / O35474* / O43854* / EGF like repeats and discoidin domains 3* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSDARG0000009341313
dcbld2 / discoidin, CUB and LCCL domain containing 2 / Q91ZV3* / Q96PD2* / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA.*ENSDARG0000006217711
dcbld1 / discoidin, CUB and LCCL domain containing 1 / Q8N8Z6* / Q9D4J3* / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA.*ENSDARG000000159079
si:dkey-34d22.1ENSDARG000001031818
hephl1a / hephaestin-like 1aENSDARG000000592316
hephl1b / hephaestin-like 1b / HEPH* / Q9BQS7* / Q9Z0Z4* / hephaestin*ENSDARG000000264036
rs1a / retinoschisin 1a / RS1* / Q9Z1L4* / O15537* / retinoschisin 1* / retinoschisis (X-linked, juvenile) 1 (human)*ENSDARG000000272366
cp / ceruloplasminENSDARG000000103125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027146  Neuropilin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Signal transduction by L1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite U-shaped , abnormal
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 ZFA:0000186 common cardinal vein common cardinal vein blood vessel endothelium patchy , abnormal
common cardinal vein cell-cell junction decreased length , abnormal
common cardinal vein actin filament bundle disoriented , abnormal
common cardinal vein actin filament bundle organization decreased process quality , abnormal
common cardinal vein blood vessel endothelial cell structure, cavities , abnormal
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 ZFA:0000213 habenula habenula axon misrouted , abnormal
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 ZFA:0000903 interpeduncular nucleus tegmentum interpeduncular nucleus tegmentum structure , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
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 ZFA:0009052 motor neuron motor neuron axon truncated , abnormal
motor neuron axon branchiness , abnormal
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 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased length , abnormal
CaP motoneuron axon branched , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / complex / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000016429 farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000011449 fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex / reaction
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction / complex






 

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