ENSGALG00000007140


Gallus gallus

Features
Gene ID: ENSGALG00000007140
  
Biological name :NRP1
  
Synonyms : neuropilin-1 precursor / NRP1
  
Possible biological names infered from orthology : neuropilin 1 / O14786 / P97333
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 13886401
Gene end: 13992667
  
Corresponding Affymetrix probe sets: Gga.15879.1.S1_s_at (Chicken Array)   Gga.4032.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063015
Ensembl peptide - ENSGALP00000011550
NCBI entrez gene - 395560     See in Manteia.
RefSeq - XM_015281290
RefSeq - NM_204782
RefSeq Peptide - NP_990113
swissprot - A0A1L1RW02
swissprot - F1N8P1
Ensembl - ENSGALG00000007140
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrp1aENSDARG00000102153Danio rerio
 NRP1ENSG00000099250Homo sapiens
 Nrp1ENSMUSG00000025810Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRP2 / neuropilin-2 precursor / O35375* / O60462* / neuropilin 2*ENSGALG0000000862145
F8 / coagulation factor VIII / P00451* / Q06194*ENSGALG0000000507718
F5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*ENSGALG0000002929817
MFGE8 / lactadherin isoform 2 precursor / P21956* / Q08431* / milk fat globule-EGF factor 8 protein*ENSGALG0000000670214
EDIL3 / EGF like repeats and discoidin domains 3 / O35474* / O43854* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSGALG0000001563013
DCBLD1 / discoidin, CUB and LCCL domain containing 1 / Q8N8Z6* / Q9D4J3* / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA.*ENSGALG0000001490712
DCBLD2 / discoidin, CUB and LCCL domain-containing protein 2 precursor / Q91ZV3* / Q96PD2* / discoidin, CUB and LCCL domain containing 2* / Mus musculus discoidin, CUB and LCCL domain cont...ENSGALG0000001525811
ENSGALG0000002906610
HEPH / hephaestin / Q9BQS7* / Q9Z0Z4*ENSGALG000000374107
ENSGALG000000307737
HEPHL1 / hephaestin like 1 / Q3V1H3* / Q6MZM0* / Hephaestin-like protein 1 *ENSGALG000000430277
RS1 / retinoschisin 1 / O15537* / Q9Z1L4* / retinoschisis (X-linked, juvenile) 1 (human)*ENSGALG000000165235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000859  CUB domain
 IPR000998  MAM domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014648  Neuropilin
 IPR022579  Neuropilin, C-terminal
 IPR027146  Neuropilin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007413 axonal fasciculation IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0021612 facial nerve structural organization IEA
 biological_processGO:0021636 trigeminal nerve morphogenesis IEA
 biological_processGO:0021637 trigeminal nerve structural organization IEA
 biological_processGO:0021649 vestibulocochlear nerve structural organization IEA
 biological_processGO:0021675 nerve development IEA
 biological_processGO:0021785 branchiomotor neuron axon guidance IEA
 biological_processGO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
 biological_processGO:0022035 rhombomere cell migration IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IEA
 biological_processGO:0036486 ventral trunk neural crest cell migration IEA
 biological_processGO:0038084 vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0038189 neuropilin signaling pathway IEA
 biological_processGO:0038190 VEGF-activated neuropilin signaling pathway IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048729 tissue morphogenesis IMP
 biological_processGO:0048841 regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IEA
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0048846 axon extension involved in axon guidance IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060385 axonogenesis involved in innervation IEA
 biological_processGO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching IEA
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis IEA
 biological_processGO:0060982 coronary artery morphogenesis IEA
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IEA
 biological_processGO:0061441 renal artery morphogenesis IEA
 biological_processGO:0061549 sympathetic ganglion development IEA
 biological_processGO:0061551 trigeminal ganglion development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:0071679 commissural neuron axon guidance IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance IEA
 biological_processGO:0097374 sensory neuron axon guidance IEA
 biological_processGO:0097475 motor neuron migration IEA
 biological_processGO:0097490 sympathetic neuron projection extension IEA
 biological_processGO:0097491 sympathetic neuron projection guidance IEA
 biological_processGO:0098743 cell aggregation IDA
 biological_processGO:0150018 basal dendrite development IEA
 biological_processGO:0150020 basal dendrite arborization IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1901166 neural crest cell migration involved in autonomic nervous system development IEA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance IEA
 biological_processGO:1902287 semaphorin-plexin signaling pathway involved in axon guidance IEA
 biological_processGO:1902336 positive regulation of retinal ganglion cell axon guidance IEA
 biological_processGO:1902378 VEGF-activated neuropilin signaling pathway involved in axon guidance IEA
 biological_processGO:1902946 protein localization to early endosome IEA
 biological_processGO:1903375 facioacoustic ganglion development IEA
 biological_processGO:1904835 dorsal root ganglion morphogenesis IEA
 biological_processGO:1905040 otic placode development IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005883 neurofilament IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0032584 growth cone membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0070852 cell body fiber IDA
 cellular_componentGO:0097443 sorting endosome IEA
 molecular_functionGO:0005021 vascular endothelial growth factor-activated receptor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0038085 vascular endothelial growth factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurophilin interactions with VEGF and VEGFR
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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