ENSGALG00000005077


Gallus gallus

Features
Gene ID: ENSGALG00000005077
  
Biological name :F8
  
Synonyms : coagulation factor VIII / F8
  
Possible biological names infered from orthology : P00451 / Q06194
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 2154809
Gene end: 2178532
  
Corresponding Affymetrix probe sets: Gga.5130.1.S1_at (Chicken Array)   GgaAffx.3340.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000031772
Ensembl peptide - ENSGALP00000044539
NCBI entrez gene - 422199     See in Manteia.
RefSeq - XM_420193
swissprot - A0A1D5NW08
swissprot - F1NPT2
Ensembl - ENSGALG00000005077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f8ENSDARG00000101385Danio rerio
 F8ENSG00000185010Homo sapiens
 F8ENSMUSG00000031196Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*ENSGALG0000002929827
HEPH / hephaestin / Q9BQS7* / Q9Z0Z4*ENSGALG0000003741019
HEPHL1 / hephaestin like 1 / Q3V1H3* / Q6MZM0* / Hephaestin-like protein 1 *ENSGALG0000004302718
ENSGALG0000003077318
MFGE8 / lactadherin isoform 2 precursor / P21956* / Q08431* / milk fat globule-EGF factor 8 protein*ENSGALG000000067028
EDIL3 / EGF like repeats and discoidin domains 3 / O35474* / O43854* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSGALG000000156308
NRP2 / neuropilin-2 precursor / O35375* / O60462* / neuropilin 2*ENSGALG000000086218
NRP1 / neuropilin-1 precursor / O14786* / P97333* / neuropilin 1*ENSGALG000000071408
DCBLD1 / discoidin, CUB and LCCL domain containing 1 / Q8N8Z6* / Q9D4J3* / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA.*ENSGALG000000149076
DCBLD2 / discoidin, CUB and LCCL domain-containing protein 2 precursor / Q91ZV3* / Q96PD2* / discoidin, CUB and LCCL domain containing 2* / Mus musculus discoidin, CUB and LCCL domain cont...ENSGALG000000152586
ENSGALG000000290665
RS1 / retinoschisin 1 / O15537* / Q9Z1L4* / retinoschisis (X-linked, juvenile) 1 (human)*ENSGALG000000165233


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR008972  Cupredoxin
 IPR008979  Galactose-binding-like domain superfamily
 IPR011706  Multicopper oxidase, type 2
 IPR014707  Coagulation factor 8
 IPR033138  Multicopper oxidases, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001780 PROC / vitamin K-dependent protein C precursor / P33587* / P04070* / protein C, inactivator of coagulation factors Va and VIIIa* / Vitamin K-dependent protein C Vitamin K-dependent protein...  / reaction
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSGALG00000026677 F10 / P25155 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / O88947* / P00742* / coagulation factor X*  / reaction
 ENSGALG00000005077 F8 / coagulation factor VIII / P00451* / Q06194*  / complex
 ENSGALG00000010017 MCFD2 / Q8K5B2* / Q8NI22* / Multiple coagulation factor deficiency * / multiple coagulation factor deficiency 2*  / complex / reaction
 ENSGALG00000034821 LMAN1 / protein ERGIC-53 precursor / P49257* / Q9D0F3* / Protein ERGIC-53 * / lectin, mannose binding 1*  / complex / reaction






 

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