ENSDARG00000101385


Danio rerio

Features
Gene ID: ENSDARG00000101385
  
Biological name :f8
  
Synonyms : coagulation factor VIII, procoagulant component / f8
  
Possible biological names infered from orthology : coagulation factor VIII / P00451 / Q06194
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 1007169
Gene end: 1040736
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130264
Ensembl peptide - ENSDARP00000135848
swissprot - A0A0R4IBQ7
swissprot - A0A0R4INL6
ZFIN ID - ZDB-GENE-090629-2
Ensembl - ENSDARG00000101385
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F8ENSGALG00000005077Gallus gallus
 F8ENSG00000185010Homo sapiens
 F8ENSMUSG00000031196Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
f5 / coagulation factor V / O88783* / P12259* / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain*ENSDARG0000005570533
cp / ceruloplasminENSDARG0000001031223
hephl1b / hephaestin-like 1b / HEPH* / Q9BQS7* / Q9Z0Z4* / hephaestin*ENSDARG0000002640323
hephl1a / hephaestin-like 1aENSDARG0000005923123
nrp2a / neuropilin 2aENSDARG0000009654610
mfge8b / milk fat globule-EGF factor 8 protein bENSDARG0000004580310
mfge8a / milk fat globule-EGF factor 8 protein aENSDARG0000001534910
nrp2b / neuropilin 2bENSDARG000000384469
nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*ENSDARG000001021539
edil3b / EGF-like repeats and discoidin I-like domains 3b / EDIL3* / O35474* / O43854* / EGF like repeats and discoidin domains 3* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSDARG000000608779
edil3a / EGF-like repeats and discoidin I-like domains 3a / EDIL3* / O35474* / O43854* / EGF like repeats and discoidin domains 3* / EGF-like repeat and discoidin I-like domain-containing protein 3 *ENSDARG000000934138
nrp1b / neuropilin 1bENSDARG000000272907
dcbld2 / discoidin, CUB and LCCL domain containing 2 / Q91ZV3* / Q96PD2* / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA.*ENSDARG000000621777
dcbld1 / discoidin, CUB and LCCL domain containing 1 / Q8N8Z6* / Q9D4J3* / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA.*ENSDARG000000159076
si:dkey-34d22.1ENSDARG000001031815
rs1a / retinoschisin 1a / RS1* / Q9Z1L4* / O15537* / retinoschisin 1* / retinoschisis (X-linked, juvenile) 1 (human)*ENSDARG000000272364


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR008972  Cupredoxin
 IPR008979  Galactose-binding-like domain superfamily
 IPR011706  Multicopper oxidase, type 2
 IPR024715  Coagulation factor 5/8-like
 IPR033138  Multicopper oxidases, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IGI
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000011 caudal artery caudal artery decreased accumulation thrombocyte , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature broken , abnormal
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 ZFA:0005037 post-vent vasculature post-vent vasculature broken , abnormal
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 ZFA:0009323 thrombocyte thrombocyte distributed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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