ENSMUSG00000031196


Mus musculus

Features
Gene ID: ENSMUSG00000031196
  
Biological name :F8
  
Synonyms : Coagulation factor VIII / F8 / Q06194
  
Possible biological names infered from orthology : P00451
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 75172715
Gene end: 75382615
  
Corresponding Affymetrix probe sets: 10605392 (MoGene1.0st)   1449558_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114207
Ensembl peptide - ENSMUSP00000117919
Ensembl peptide - ENSMUSP00000033539
Ensembl peptide - ENSMUSP00000109719
NCBI entrez gene - 14069     See in Manteia.
MGI - MGI:88383
RefSeq - XM_006527792
RefSeq - NM_001161373
RefSeq - NM_001161374
RefSeq - NM_007977
RefSeq - XM_006527789
RefSeq - XM_006527790
RefSeq - XM_006527791
RefSeq Peptide - NP_032003
RefSeq Peptide - NP_001154846
RefSeq Peptide - NP_001154845
swissprot - B1AW26
swissprot - Q06194
swissprot - D3YW61
swissprot - B2RRC9
Ensembl - ENSMUSG00000031196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f8ENSDARG00000101385Danio rerio
 F8ENSGALG00000005077Gallus gallus
 F8ENSG00000185010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657928
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG0000003193617
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG0000003120917
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG0000000361716
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG000000344888
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG000000258107
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG000000259697
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG000000306057
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG000000351076
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198913
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG000000312933


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR008972  Cupredoxin
 IPR008979  Galactose-binding-like domain superfamily
 IPR011706  Multicopper oxidase, type 2
 IPR011707  Multicopper oxidase, type 3
 IPR014707  Coagulation factor 8
 IPR024715  Coagulation factor 5/8-like
 IPR033138  Multicopper oxidases, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: F8tm1Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: F8tm2Kaz/Y,Tg(Alb-F8)EBmre/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005000 immune tolerance "the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgtm1Imx/Y
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: F8tm1Kaz/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012328 decreased circulating factor VIII level "reduced levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin" [MeSH:D12.776.124.125.350, MPD:Molly]
Show

Allelic Composition: Clec4ntm1Yiw/Clec4ntm1Yiw
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: F8tm1.1Rmnt/F8tm1.1Rmnt,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: F8tm1.1Rmnt/F8tm1.1Rmnt,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024150 Mcfd2 / Q8K5B2 / Multiple coagulation factor deficiency / Q8NI22* / multiple coagulation factor deficiency 2*  / complex / reaction
 ENSMUSG00000041891 Lman1 / Q9D0F3 / Protein ERGIC-53 / P49257* / lectin, mannose binding 1*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000031196 F8 / Q06194 / Coagulation factor VIII / P00451*  / complex
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction / complex
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / reaction






 

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