ENSMUSG00000030605


Mus musculus

Features
Gene ID: ENSMUSG00000030605
  
Biological name :Mfge8
  
Synonyms : Mfge8 / milk fat globule-EGF factor 8 protein / P21956
  
Possible biological names infered from orthology : Q08431
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79133768
Gene end: 79149060
  
Corresponding Affymetrix probe sets: 10564713 (MoGene1.0st)   1420911_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145720
Ensembl peptide - ENSMUSP00000032825
Ensembl peptide - ENSMUSP00000103032
NCBI entrez gene - 17304     See in Manteia.
MGI - MGI:102768
RefSeq - NM_001045489
RefSeq - NM_008594
RefSeq Peptide - NP_001038954
RefSeq Peptide - NP_032620
swissprot - A0A0U1RNV7
swissprot - P21956
Ensembl - ENSMUSG00000030605
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MFGE8ENSGALG00000006702Gallus gallus
 MFGE8ENSG00000140545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG0000003448848
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119636
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657935
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG0000002596926
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG0000002581025
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG0000003510721
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG0000003129312
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG000000312099
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG000000036178
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG000000319368
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000742  EGF-like domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR027060  Lactadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006910 phagocytosis, recognition IDA
 biological_processGO:0006911 phagocytosis, engulfment IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0043277 apoptotic cell clearance IDA
 biological_processGO:0050766 positive regulation of phagocytosis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: B6.129P2-Mfge8Gt(KST227)Byg

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: B6.129P2-Mfge8Gt(KST227)Byg

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: B6.129P2-Mfge8Gt(KST227)Byg

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mfge8tm1Shur/Mfge8tm1Shur
Genetic Background: B6.129-Mfge8tm1Shur

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: B4galnt1tm1Rlp/B4galnt1+,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfge8tm1Shur/Mfge8tm1Shur
Genetic Background: B6.129-Mfge8tm1Shur

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfge8tm1Shur/Mfge8tm1Shur
Genetic Background: B6.129-Mfge8tm1Shur

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: B6.129P2-Mfge8Gt(KST227)Byg

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004934 epididymis epithelium degeneration "pathological deterioration of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Shur/Mfge8tm1Shur
Genetic Background: B6.129-Mfge8tm1Shur

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcyt1btm1Mkar/Pcyt1b+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009824 spermatic granuloma "a granulomatous nodular lesion that appears in the region of epididymis and can be large enough to totally occlude the epididymal lumen; sperm granulomas are rounded or irregular in shape, and contain dense aggregates of immune cells and degenerating sperm resulting from an autoimmune response against sperm-associated antigens exposed following biochemical or surgical insult (e.g. vasectomy) to the epididymal epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Shur/Mfge8tm1Shur
Genetic Background: B6.129-Mfge8tm1Shur

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Mfge8tm1Mcu/Mfge8tm1Mcu
Genetic Background: involves: 129X1/SvJ * C57BL/6NCr

 MP:0013148 mastitis "inflammation of the teats or mammary glands" [MGI:Ahmad_Retha]
Show

Allelic Composition: Mfge8Gt(KST227)Byg/Mfge8Gt(KST227)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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