ENSMUSG00000034488


Mus musculus

Features
Gene ID: ENSMUSG00000034488
  
Biological name :Edil3
  
Synonyms : Edil3 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O35474
  
Possible biological names infered from orthology : EGF like repeats and discoidin domains 3 / O43854
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C3
Gene start: 88821472
Gene end: 89323223
  
Corresponding Affymetrix probe sets: 10406504 (MoGene1.0st)   1425622_at (Mouse Genome 430 2.0 Array)   1425842_at (Mouse Genome 430 2.0 Array)   1433474_at (Mouse Genome 430 2.0 Array)   1440674_at (Mouse Genome 430 2.0 Array)   1446573_at (Mouse Genome 430 2.0 Array)   1458867_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044652
Ensembl peptide - ENSMUSP00000080462
Ensembl peptide - ENSMUSP00000112829
NCBI entrez gene - 13612     See in Manteia.
MGI - MGI:1329025
RefSeq - NM_010103
RefSeq - NM_001037987
RefSeq Peptide - NP_001033076
RefSeq Peptide - NP_034233
swissprot - O35474
swissprot - Q8C4U8
swissprot - Q8C8K0
Ensembl - ENSMUSG00000034488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edil3aENSDARG00000093413Danio rerio
 edil3bENSDARG00000060877Danio rerio
 EDIL3ENSGALG00000015630Gallus gallus
 EDIL3ENSG00000164176Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG0000003060546
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119638
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657935
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG0000002581027
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG0000002596926
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG0000003510721
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG0000003129313
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG0000003120910
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG0000003193610
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG000000036179
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR029828  EGF-like repeat and discoidin I-like domain-containing protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Porcntm1.1Lcm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndptm2Nat/Ndp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fzd4tm1Nat/Fzd4+,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pkd1tm1Shh/Pkd1tm1.1Pcha
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Smad2tm1Rob/Smad2tm2.1Rob
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Zic3tm1.1Smwa/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ubr4tm1.1Nkt/Ubr4tm1.1Nkt
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Prickle1tm1.3Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ubr4tm1.1Nkt/Ubr4tm1.1Nkt
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000566 synostosis "osseous union of two bones that are not normally connected" [J:13049]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: LdlrRgsc366/Ldlr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Bcl2tm2.1Lbox/Bcl2tm2.1Lbox
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Ubr4tm1.1Nkt/Ubr4tm1.1Nkt
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Eif1atm1Tcrl/Eif1a+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0000933 abnormal rhombomere morphology "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Smad4tm1.1Rob/Smad4+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: (TSJ/Le x AKR/J)F1

Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: (TSJ/Le x AKR/J)F1

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Nsdhltm1.1Hrm/Nsdhl+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fzd5tm1Nat/Fzd5tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Nsdhltm1.1Hrm/Nsdhl+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Prkdcscid/Prkdcscid,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001296 macrophthalmia "increased average size of the eyes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gsk3atm1Dral/Gsk3atm1Dral,Gsk3btm1Dral/Gsk3btm1Dral,Gys1tm1.1Arte/Gys1tm1.1Arte
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptentm1Ppp/Pten+,Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/Sv * C3H * C57BL/6 * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Porcntm1.1Lcm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Strip1tm1b(KOMP)Wtsi/Strip1tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * CBA * FVB/NJ * SJL

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Eomestm1Rob/Eomestm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eomestm1Rob/Eomestm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zic3tm1.1Smwa/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgif1tm1Dwot/Tgif1tm1Dwot,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: LdlrRgsc366/Ldlr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Smad4tm1.1Rob/Smad4+
Genetic Background: involves: 129S/SvEv * CD-1

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Sall4tm1Tre/Sall4tm1Tre
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otud5tm1Vmd/Otud5tm1Vmd,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eomestm1.1Rob/Eomestm1.1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bak1tm1Thsn/Bak1tm1Thsn,Bcl2l1tm1Dlo/Bcl2l1+
Genetic Background: B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Cyp19a1-cre)5912Gle/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: (TSJ/Le x AKR/J)F1

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Zic3tm1.1Smwa/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

Allelic Composition: Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

Allelic Composition: Cul4btm1.1Pz/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ddx3xtm1.1Lyou/Ddx3x+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Eomestm1.1Rob/Eomes+,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Eomestm1Rob/Eomestm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Evc2tm1.1Mis/Evc2tm1.1Mis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Edil3tm1Tq/Edil3tm1Tq,Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129 * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Eif1atm1Tcrl/Eif1a+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0003381 vitreal fibroplasia "production of excess fibrous tissue in the vitreous body of the eye" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003613 abnormal kidney medulla development 
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prickle1tm1.2Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003815 nude "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Eomestm1Rob/Eomestm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Eomestm1Rob/Eomestm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

Allelic Composition: Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Fzd4tm1Nat/Fzd4+,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Cdx2tm1Fbe/Cdx2tm2Fbe,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Lhx1tm1Bhr/Lhx1tm2.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Strip1tm1b(KOMP)Wtsi/Strip1tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * CBA * FVB/NJ * SJL

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0004323 sternum hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004360 absent ulna "missing the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004476 absent palatine bone "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0004538 abnormal maxillary shelf "any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004575 small limb buds "reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004815 abnormal somatic hypermutation frequency "any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il33tm1Amgn/Il33tm1Amgn
Genetic Background: B6.129-Il33tm1Amgn

 MP:0004887 decreased endolymph production "reduced synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Eif1atm1Tcrl/Eif1a+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005163 cyclopia "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0005313 absent adrenal gland "missing endocrine glands that are normally located above the kidney and responsible for hormone and epinepherine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56651]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Nsdhltm1.1Hrm/Nsdhl+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Rdh10tm2Ics/Rdh10tm2Ics
Genetic Background: Not Specified

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+,Kdrtm1(cre)Sato/Kdr+,Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd

 MP:0006290 proboscis "a long, cylindric protuberance of the face that, in cyclopia or ethmocephaly, represents the nose" [J:92058, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008308 small scala media "reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0008513 thin retinal inner plexiform layer "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008753 abnormal osteocyte morphology "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Enpp2tm1.1Vart/Enpp2tm1.1Vart,Sox1tm2Vep/Sox1+
Genetic Background: involves: C57BL/6

Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

Allelic Composition: Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

Allelic Composition: Gt(ROSA)26Sortm6(Vegfa*)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

Allelic Composition: Gt(ROSA)26Sortm10(Gata2)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0008903 abnormal mesenteric fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mesentery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0008926 abnormal anterior definitive endoderm morphology "any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009022 abnormal brain meninges morphology "any structural anomaly in any of the membranes covering the brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009026 abnormal brain pia mater morphology "any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009266 abnormal mesendoderm development "failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0009323 abnormal spleen development "aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009445 osteomalacia "gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009573 abnormal right lung middle lobe morphology 
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Edil3tm1Tq/Edil3tm1Tq,Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129 * C57BL/6

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0009867 abnormal ascending aorta morphology "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009869 abnormal descending aorta morphology "any strucutral anomaly of the part of the aorta extending from the arch of aorta to the point where it divides into the common iliac arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzd4tm1Nat/Fzd4+,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009901 abnormal frontonasal prominence morphology "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Disp1icb/Disp1icb
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0010126 abnormal distal visceral endoderm morphology "any structural anomaly of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17387317]
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Allelic Composition: Nodaltm1Rob/Nodaltm5Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010235 abnormal retina inner limiting membrane morphology "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0010387 abnormal Bergmann glial cell morphology "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010437 absent coronary sinus "absence of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010743 delayed suture closure "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0010807 abnormal stomach position or orientation "the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0010853 abnormal lung position or orientation "the lung is displaced from the normal position and/or has an altered left/right orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Foxp2tm1Sfis/Foxp2tm1.2Sfis,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Prickle1tm1.3Asw/Prickle1tm1.3Asw,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Eif1atm1Tcrl/Eif1a+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Disp1icb/Disp1icb
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Porcntm1.1Lcm/Porcn+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2.1Kem,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Trpm7tm1Clph/Trpm7tm1.1Clph,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/0,Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Sall4tm2Tre/Sall4tm2.1Tre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * CD-1

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Abcb7tm1Mdf/Abcb7+,Tg(Gata1-cre)1Sho/0
Genetic Background: either: (involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N) or (involves: 129S4/SvJae * C57BL/6J * FVB/N)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

Allelic Composition: Myctm2.1Atp/Myctm2.1Atp,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Wnt7atm1Amc/Wnt7atm1Amc,Wnt7btm1Parr/Wnt7btm2Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA

Allelic Composition: Casz1tm1.1Flc/Casz1tm1.1Flc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Elavl1tm1Dkon/Elavl1tm1Dkon,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Porcntm1.1Lcm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Mapk11tm1Jsca/Mapk11tm1Jsca,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)

Allelic Composition: Ubr4tm1.2Nkt/Ubr4tm1.2Nkt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Allelic Composition: Slc13a4tm1c(EUCOMM)Wtsi/Slc13a4tm1d(EUCOMM)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

Allelic Composition: Erbb3tm1.1Dwt/Erbb3tm2.1Dwt,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Fzd4tm1Nat/Fzd4+,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Lrp5tm1Kry/Lrp5tm1Kry,Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Zic3tm2.1Jwb/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA

Allelic Composition: Eif1atm1Tcrl/Eif1a+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011144 thin lung-associated mesenchyme "decreased thickness of the mesenchymal cell layer in the developing lung" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011156 abnormal hypodermis fat layer morphology "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
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Allelic Composition: Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Eomestm1Rob/Eomestm1.1Rob,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Strip1tm1b(KOMP)Wtsi/Strip1tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * CBA * FVB/NJ * SJL

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0011345 truncated loop of Henle "failure of the developing loop of Henle to elongate and extend into the medullary zone of the kidney" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011438 absent kidney medulla "failure of the inner portion of the kidney, normally consisting of the renal pyramids, to form" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011439 abnormal kidney cell proliferation "anomaly in the ability of any kidney cell population to undergo expansion by cell division" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011441 decreased kidney cell proliferation "decrease in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011504 abnormal limb long bone morphology 
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
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Allelic Composition: Wnt7btm2Amc/Wnt7btm2.1Amc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Fndc3aGt(RRP208)Byg/Fndc3asys
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

 MP:0012083 absent foregut "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012084 truncated foregut "shortened foregut that terminates abruptly as if having an end or point cut off" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012086 absent hindgut "absence of the caudal portion of the primitive digestive tube of the embryo" [MGI:anna]
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Allelic Composition: Smad4tm1Rob/Smad4tm1.1Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * CD-1

 MP:0012087 absent midbrain "absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012091 increased midbrain size "greater than average size of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * CD-1

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012139 increased forebrain size "greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Smad2tm1Rob/Smad2tm2Rob,Smad3tm1Xfw/Smad3+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1

Allelic Composition: Eomestm1Rob/Eomes+,Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Nodaltm1Rob/Nodal+,Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
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Allelic Composition: Trim28tm1.1Ipc/Trim28tm1.2Ipc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Strip1tm1b(KOMP)Wtsi/Strip1tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * CBA * FVB/NJ * SJL

 MP:0012175 flat face "the appearance of a flattened surface outline or contour of a normally rounded face of an organism" [MGI:anna]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0012671 retinal spots "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [MGI:csmith]
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Allelic Composition: Lama1tm1Olf/Lama1tm1Olf,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Trim33tm1.1Los/Trim33tm1.2Los,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
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Allelic Composition: Edil3Tg(Sox2-cre)1Amc/Edil3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Gli3tm1Alj/Gli3+,Tgif1tm1Caw/Tgif1tm1Caw,Tgif2tm1Dwot/Tgif2tm1Dwot,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

Allelic Composition: Ddx3xtm1.1Lyou/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0014078 small intestinal villus atrophy "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0014082 decreased small intestinal villus height "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0014104 decreased chondrocyte apoptosis "reduced number of chondrocytes undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
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Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Fam20ctm1.1Cqi/Fam20ctm1.1Cqi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0020333 enhanced leukocyte tethering or rolling "enhancement of the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Mecp2tm1.1Bird/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0020391 radial glial endfoot detachment "detachment of the radial glia cell endfoot from the pial basement membrane" [MGI:anna, PMID:17715063, PMID:23217742, PMID:24256719]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0030538 abnormal notochordal plate morphology "any structural anomaly of the dorsal part of the notochordal process when the ventral portion breaks down; it is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube; the folding off of the notochordal plate gives rise to the notochord" [UBERON:0006267]
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Allelic Composition: Rac1tm1Tyb/Rac1tm2Tyb,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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