ENSMUSG00000003617


Mus musculus

Features
Gene ID: ENSMUSG00000003617
  
Biological name :Cp
  
Synonyms : Ceruloplasmin / Cp / Q61147
  
Possible biological names infered from orthology : P00450
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A2
Gene start: 19957054
Gene end: 20009145
  
Corresponding Affymetrix probe sets: 10490989 (MoGene1.0st)   1417494_a_at (Mouse Genome 430 2.0 Array)   1417495_x_at (Mouse Genome 430 2.0 Array)   1417496_at (Mouse Genome 430 2.0 Array)   1417497_at (Mouse Genome 430 2.0 Array)   1441326_at (Mouse Genome 430 2.0 Array)   1448734_at (Mouse Genome 430 2.0 Array)   1448735_at (Mouse Genome 430 2.0 Array)   1455393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134347
Ensembl peptide - ENSMUSP00000133643
Ensembl peptide - ENSMUSP00000133676
Ensembl peptide - ENSMUSP00000003714
Ensembl peptide - ENSMUSP00000088857
Ensembl peptide - ENSMUSP00000103961
Ensembl peptide - ENSMUSP00000103964
Ensembl peptide - ENSMUSP00000103965
Ensembl peptide - ENSMUSP00000133374
NCBI entrez gene - 12870     See in Manteia.
MGI - MGI:88476
RefSeq - XM_017319446
RefSeq - NM_001276248
RefSeq - NM_001276250
RefSeq - NM_007752
RefSeq - XM_006535381
RefSeq - XM_011249655
RefSeq Peptide - NP_001263179
RefSeq Peptide - NP_031778
RefSeq Peptide - NP_001263177
swissprot - G3UXD2
swissprot - G3UXG1
swissprot - G3UZ53
swissprot - G3X8Q5
swissprot - G3UWP5
swissprot - G3X9T8
swissprot - Q61147
swissprot - E9PZD8
Ensembl - ENSMUSG00000003617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CPENSG00000047457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG0000003193648
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG0000003120948
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119634
F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*ENSMUSG0000002657933
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG000000259697
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198915
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG000000258105
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG000000351075
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG000000344884
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG000000312933
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG000000306053


Protein motifs (from Interpro)
Interpro ID Name
 IPR001117  Multicopper oxidase, type 1
 IPR002355  Multicopper oxidase, copper-binding site
 IPR008972  Cupredoxin
 IPR011706  Multicopper oxidase, type 2
 IPR011707  Multicopper oxidase, type 3
 IPR024715  Coagulation factor 5/8-like
 IPR027150  Ceruloplasmin
 IPR033138  Multicopper oxidases, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006825 copper ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004322 ferroxidase activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Metal ion SLC transporters
Post-translational protein phosphorylation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cptm1Yos/Cptm1Yos
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.2Jdun/Hephtm1.2Jdun
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.2Jdun/Hephtm1.2Jdun
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.1Jdun/Hephtm1.1Jdun,Tg(BEST1-cre)1Jdun/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.1Jdun/Hephtm1.1Jdun,Tg(BEST1-cre)1Jdun/0,Tg(Rho-cre)#Yzl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Hephsla
Genetic Background: involves: 129X1/SvJ

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Yos/Cptm1Yos
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.2Jdun/Hephtm1.2Jdun
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003065 abnormal hepatic copper content "anomalous level of copper present in the liver tissue" [RGD:Rat Genome Database submission]
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Yos/Cptm1Yos
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cpm1Btlr/Cpm1Btlr
Genetic Background: C57BL/6J-Cpm1Btlr

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Hephsla
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.1Jdun/Hephtm1.1Jdun,Tg(BEST1-cre)1Jdun/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Hephsla
Genetic Background: involves: 129X1/SvJ

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.1Jdun/Hephtm1.1Jdun,Tg(BEST1-cre)1Jdun/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0005549 retinal pigment epithelium hyperplasia "increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

 MP:0005638 hemochromatosis "disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:64456]
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Allelic Composition: Lmx1btm4.1Rjo/Lmx1btm4.1Rjo,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: CpR435X/CpR435X,Hfetm1Sly/Hfetm1Sly
Genetic Background: involves: C3H/DiSnA * C57BL/10ScSnA

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephtm1.1Jdun/Hephtm1.1Jdun,Tg(BEST1-cre)1Jdun/0,Tg(Rho-cre)#Yzl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

Allelic Composition: Cptm1Yos/Cptm1Yos
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cpm1Btlr/Cpm1Btlr
Genetic Background: C57BL/6J-Cpm1Btlr

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

 MP:0008811 abnormal brain iron level "any anomaly in the amount of iron present in the brain tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0011890 increased circulating ferritin level "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

 MP:0011896 increased circulating unsaturated transferrin level "increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
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Allelic Composition: Cptm1Samd/Cptm1Samd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012661 decreased circulating ceruloplasmin level 
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Allelic Composition: Artm1Reb/Y,Tg(Amh-cre)8815Reb/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

 MP:0014175 abnormal ciliary epithelium morphology "any structural anomaly of the double layer lining the inner surfaces of the ciliary processes and the pars plana (i.e. the posterior portion of the ciliary body, aka orbicularis ciliari); the outer layer is the pigmented epithelium, which is composed of low cuboidal cells and is adjacent to the stroma and continuous with the retinal pigmented epithelium; the inner layer is formed by non-pigmented epithelium, a columnar epithelium, adjacent to the aqueous humor in the posterior chamber and continuous with the retina; these two layers of the epithelium are appositioned in their apical surfaces" [http://cdn.intechopen.com/pdfs-wm/41830.pdf]
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Allelic Composition: Cptm1Hrs/Cptm1Hrs,Hephsla/Y
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025993 Q9JHI9 / Slc40a1 / solute carrier family 40 (iron-regulated transporter), member 1 / Q9NP59* / solute carrier family 40 member 1*  / complex






 

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