Manteia - Molecule gene

ENSMUSG00000025993

Mus musculus

Features

Gene ID:	ENSMUSG00000025993

Biological name :	Slc40a1

Synonyms :	Q9JHI9 / Slc40a1 / solute carrier family 40 (iron-regulated transporter), member 1

Possible biological names infered from orthology :	Q9NP59 / solute carrier family 40 member 1

Species:	Mus musculus

Chr. number:	1
Strand:	-1
Band:	C1.1
Gene start:	45908068
Gene end:	45926523

Corresponding Affymetrix probe sets:	10354374 (MoGene1.0st) 1417061_at (Mouse Genome 430 2.0 Array) 1448566_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000140969 Ensembl peptide - ENSMUSP00000027137 Ensembl peptide - ENSMUSP00000140549 Ensembl peptide - ENSMUSP00000140734 NCBI entrez gene - 53945 See in Manteia. MGI - MGI:1315204 RefSeq - NM_016917 RefSeq - XM_006496137 RefSeq - XM_017321709 RefSeq Peptide - NP_058613 swissprot - C5H8V4 swissprot - Q9JHI9 Ensembl - ENSMUSG00000025993

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
slc40a1	ENSDARG00000000241	Danio rerio
SLC40A1	ENSGALG00000043618	Gallus gallus
Q9NP59	ENSG00000138449	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR009716	Ferroporti-1
IPR036259	MFS transporter superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002260	lymphocyte homeostasis	IMP
biological_process	GO:0003158	endothelium development	IMP
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006826	iron ion transport	IDA
biological_process	GO:0006879	cellular iron ion homeostasis	IEA
biological_process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	IDA
biological_process	GO:0034755	iron ion transmembrane transport	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
biological_process	GO:0048536	spleen development	IMP
biological_process	GO:0055072	iron ion homeostasis	IMP
biological_process	GO:0060345	spleen trabecula formation	IMP
biological_process	GO:0060586	multicellular organismal iron ion homeostasis	IMP
biological_process	GO:1903988	ferrous iron export across plasma membrane	IDA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0008021	synaptic vesicle	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016323	basolateral plasma membrane	IEA
molecular_function	GO:0005381	iron ion transmembrane transporter activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0015093	ferrous iron transmembrane transporter activity	IDA
molecular_function	GO:0017046	peptide hormone binding	IEA
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0097689	iron channel activity	IDA

Pathways (from Reactome)

Pathway description

Metal ion SLC transporters

Iron uptake and transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ighg1^tm3Cgn/Ighg1⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df Allelic Composition: Slc40a1^ffe/Slc40a1^ffe Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df
MP:0001944	abnormal pancreas morphology	"malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0002608	increased hematocrit	"greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0002642	anisocytosis	"blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0002643	poikilocytosis	"blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0002872	polycythemia	"an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Mtor^tm1.2Koz/Mtor^tm1.2Koz,Tg(ACTA1-cre)79Jme/? Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm
MP:0003720	abnormal neural tube closure	"abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df
MP:0003795	abnormal bone structure		Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0003998	decreased thermal nociceptive threshold	"a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sele^tm1Alb/Sele^tm1Alb Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004151	hypoferremia	"less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm
MP:0004357	long tibia	"increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0005319	abnormal enzyme/ coenzyme level	"altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0005637	abnormal iron homeostasis	"anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005638	hemochromatosis	"disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:64456]	Show Allelic Composition: Ednrb^s-2Btlr/Ednrb^s-2Btlr Genetic Background: C57BL/6J-Ednrb^s-2Btlr
MP:0008388	hypochromic microcytic anemia	"hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm
MP:0008737	abnormal spleen physiology	"any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm
MP:0008738	abnormal liver iron level	"anomaly in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0008743	decreased liver iron level	"reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2 Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm
MP:0008807	increased liver iron level	"increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008808	decreased spleen iron level	"reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2 Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008809	increased spleen iron level	"increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
MP:0008810	increased circulating iron level	"elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009146	abnormal pancreatic acinar cell morphology	"any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009322	increased splenocyte apoptosis	"increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm
MP:0009323	abnormal spleen development	"aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^Pcm/Slc40a1^Pcm Genetic Background: A.Cg-Slc40a1^Pcm Allelic Composition: Slc40a1^Pcm/Slc40a1⁺ Genetic Background: A.Cg-Slc40a1^Pcm
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0010175	leptocytosis	"the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull s-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)
MP:0010375	increased kidney iron level	"increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df Allelic Composition: Slc40a1^ffe/Slc40a1^ffe Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0011097	complete embryonic lethality before turning of embryo	"death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Sele^tm1Alb/Sele^tm1Alb Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0011106	partial embryonic lethality before somite formation	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Rel^tm1Hcl/Rel⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011886	increased circulating lipase level	"elevated blood level of lipase in the blood, in particular the serum" [MGI:csmith]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011890	increased circulating ferritin level	"elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J) Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011896	increased circulating unsaturated transferrin level	"increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]	Show Allelic Composition: Slc40a1^ffe/Slc40a1⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)
MP:0011897	decreased circulating unsaturated transferrin level	"reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Slc24a5^{tm1b(KOMP)Mbp}/Slc24a5^{tm1b(KOMP)Mbp} Genetic Background: C57BL/6N-Slc24a5^{tm1b(KOMP)Mbp}/J
MP:0013302	increased pancreas iron level	"increase in the amount of iron present in the pancreas tissue" [MGI:mlaw]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0020365	increased brain iron level	"increase in the amount of iron present in the brain tissue" [MGI:Anna]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0020367	increased heart iron level	"increase in the amount of iron present in the heart tissue" [MGI:Anna]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0020369	increased intestinal iron level	"increase in the amount of iron present in the large or small intestinal tissue" [MGI:Anna]	Show Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺,Slc40a1^tm2Nca/Slc40a1^tm2Nca Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac Allelic Composition: Slc40a1^tm2Nca/Slc40a1^tm2Nca,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0020385	decreased intestinal iron level	"reduction in the amount of iron present in the large or small intestinal tissue" [MGI:Anna]	Show Allelic Composition: Slc40a1^tm1.1Mmfe/Slc40a1^tm1.1Mmfe Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003617	Cp / Q61147 / Ceruloplasmin / P00450*	/ complex
ENSMUSG00000031209	Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*	/ complex

1 s.

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