ENSMUSG00000026579


Mus musculus

Features
Gene ID: ENSMUSG00000026579
  
Biological name :F5
  
Synonyms : Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / F5 / O88783
  
Possible biological names infered from orthology : coagulation factor V / P12259
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.2
Gene start: 164151838
Gene end: 164220277
  
Corresponding Affymetrix probe sets: 10351224 (MoGene1.0st)   1418907_at (Mouse Genome 430 2.0 Array)   1449269_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083204
NCBI entrez gene - 14067     See in Manteia.
MGI - MGI:88382
RefSeq - NM_007976
RefSeq Peptide - NP_032002
swissprot - O88783
Ensembl - ENSMUSG00000026579
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f5ENSDARG00000055705Danio rerio
 F5ENSGALG00000029298Gallus gallus
 F5ENSG00000198734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F8 / Q06194 / Coagulation factor VIII / P00451*ENSMUSG0000003119629
Heph / Q9Z0Z4 / Hephaestin / Q9BQS7*ENSMUSG0000003120918
Hephl1 / Q3V1H3 / Hephaestin-like protein 1 / Q6MZM0* / hephaestin like 1*ENSMUSG0000003193617
Cp / Q61147 / Ceruloplasmin / P00450*ENSMUSG0000000361716
Edil3 / O35474 / EGF-like repeat and discoidin I-like domain-containing protein 3 / O43854* / EGF like repeats and discoidin domains 3*ENSMUSG000000344888
Nrp1 / P97333 / Neuropilin-1 / O14786*ENSMUSG000000258107
Nrp2 / O35375 / Neuropilin-2 / O60462*ENSMUSG000000259697
Mfge8 / P21956 / milk fat globule-EGF factor 8 protein / Q08431*ENSMUSG000000306057
Dcbld2 / Q91ZV3 / Mus musculus discoidin, CUB and LCCL domain containing 2 (Dcbld2), transcript variant 2, mRNA. / Q96PD2* / discoidin, CUB and LCCL domain containing 2*ENSMUSG000000351076
Rs1 / Q9Z1L4 / retinoschisis (X-linked, juvenile) 1 (human) / O15537* / retinoschisin 1*ENSMUSG000000312934
Dcbld1 / Q9D4J3 / Mus musculus discoidin, CUB and LCCL domain containing 1 (Dcbld1), transcript variant 2, mRNA. / Q8N8Z6* / discoidin, CUB and LCCL domain containing 1*ENSMUSG000000198914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR008972  Cupredoxin
 IPR008979  Galactose-binding-like domain superfamily
 IPR011707  Multicopper oxidase, type 3
 IPR024715  Coagulation factor 5/8-like
 IPR033138  Multicopper oxidases, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008015 blood circulation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031091 platelet alpha granule IDA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
COPII-mediated vesicle transport
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Cargo concentration in the ER
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

Allelic Composition: F5tm2Dgi/F5tm2Dgi,Proztm1Gjb/Proztm1Gjb
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp7aMo-pew/Y
Genetic Background: CBA/J-Atp7aMo-pew

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: B6N.129-Mstntm1Sjl

Allelic Composition: F5tm2Dgi/F5tm2Dgi,Proztm1Gjb/Proztm1Gjb
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: F5tm2Dgi/F5tm2Dgi,Proztm1Gjb/Proz+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: F5tm2Dgi/F5+
Genetic Background: B6.129S2-F5tm2Dgi

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: F5tm2Dgi/F5+
Genetic Background: B6.129S2-F5tm2Dgi

Allelic Composition: F5tm2Dgi/F5tm2Dgi,Proztm1Gjb/Proztm1Gjb
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: F5tm2Dgi/F5tm2Dgi,Proztm1Gjb/Proz+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
Show

Allelic Composition: Atp7aMo-pew/Y
Genetic Background: CBA/J-Atp7aMo-pew

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi,Serpina10tm1Gjb/Serpina10tm1Gjb
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: F5tm2Dgi/F5+,Serpina10tm1Gjb/Serpina10tm1Gjb
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: 129S1(Cg)-F5tm2Dgi

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: 129S1(Cg)-F5tm2Dgi

Allelic Composition: F5tm2Dgi/F5tm2Dgi,MF5L6/MF5L6+,Tfpitm1Gjb/Tfpi+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024150 Mcfd2 / Q8K5B2 / Multiple coagulation factor deficiency / Q8NI22* / multiple coagulation factor deficiency 2*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000041891 Lman1 / Q9D0F3 / Protein ERGIC-53 / P49257* / lectin, mannose binding 1*  / complex / reaction
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction / complex
 ENSMUSG00000026579 F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*  / complex
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / reaction






 

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