Manteia - Molecule gene

ENSMUSG00000041891

Mus musculus

Features

Gene ID:	ENSMUSG00000041891

Biological name :	Lman1

Synonyms :	Lman1 / Protein ERGIC-53 / Q9D0F3

Possible biological names infered from orthology :	lectin, mannose binding 1 / P49257

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E1
Gene start:	65980754
Gene end:	66022580

Corresponding Affymetrix probe sets:	10459481 (MoGene1.0st) 1419951_at (Mouse Genome 430 2.0 Array) 1428129_at (Mouse Genome 430 2.0 Array) 1428130_at (Mouse Genome 430 2.0 Array) 1444037_at (Mouse Genome 430 2.0 Array) 1452671_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000116433 Ensembl peptide - ENSMUSP00000040140 Ensembl peptide - ENSMUSP00000113326 NCBI entrez gene - 70361 See in Manteia. MGI - MGI:1917611 RefSeq - NM_001172062 RefSeq - NM_027400 RefSeq Peptide - NP_001165533 RefSeq Peptide - NP_081676 swissprot - D3Z5B9 swissprot - Q9D0F3 Ensembl - ENSMUSG00000041891

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lman1	ENSDARG00000069980	Danio rerio
LMAN1	ENSGALG00000034821	Gallus gallus
LMAN1	ENSG00000074695	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lman1l / Q8VCD3 / Protein ERGIC-53-like / Q9HAT1* / lectin, mannose binding 1 like*	ENSMUSG00000056271	30
Lman2 / Q9DBH5 / Vesicular integral-membrane protein VIP36 / Q12907* / lectin, mannose binding 2*	ENSMUSG00000021484	20
Lman2l / P59481 / VIP36-like protein / Q9H0V9* / lectin, mannose binding 2 like*	ENSMUSG00000001143	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR005052	Legume-like lectin
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR033085	Protein ERGIC-53

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006888	ER to Golgi vesicle-mediated transport	IEA
biological_process	GO:0007029	endoplasmic reticulum organization	IMP
biological_process	GO:0007030	Golgi organization	ISO
biological_process	GO:0010638	positive regulation of organelle organization	ISO
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0016192	vesicle-mediated transport	IEA
cellular_component	GO:0000139	Golgi membrane	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	ISO
cellular_component	GO:0005794	Golgi apparatus	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030017	sarcomere	IDA
cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	IDA
cellular_component	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	IEA
cellular_component	GO:0044220	host cell perinuclear region of cytoplasm	ISO
molecular_function	GO:0005537	mannose binding	IEA
molecular_function	GO:0030246	carbohydrate binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

COPII-mediated vesicle transport

Cargo concentration in the ER

Transport to the Golgi and subsequent modification

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0004720	abnormal platelet morphology	"any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Lman1^{tm1c(KOMP)Wtsi}/Lman1^{tm1c(KOMP)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N
MP:0009378	abnormal endoplasmic reticulum morphology	"any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]	Show Allelic Composition: Dnah5^b2b002Clo/Dnah5^b2b002Clo Genetic Background: C57BL/6J-Dnah5^b2b002Clo
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lman1^{tm1c(KOMP)Wtsi}/Lman1^{tm1c(KOMP)Wtsi},Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N Allelic Composition: Lman1^{tm1c(KOMP)Wtsi}/Lman1^{tm1c(KOMP)Wtsi},Tg(Tek-cre)12Flv/0 Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Dnah5^b2b002Clo/Dnah5^b2b002Clo Genetic Background: C57BL/6J-Dnah5^b2b002Clo
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Dnah5^b2b002Clo/Dnah5^b2b002Clo Genetic Background: C57BL/6J-Dnah5^b2b002Clo Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg} Genetic Background: D2.129P2-Lman1^{Gt(XST010)Byg}

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000016256	Ctsz / Q9WUU7 / cathepsin Z / Q9UBR2*	/ complex / reaction
ENSMUSG00000024150	Mcfd2 / Q8K5B2 / Multiple coagulation factor deficiency / Q8NI22* / multiple coagulation factor deficiency 2*	/ complex
ENSMUSG00000031196	F8 / Q06194 / Coagulation factor VIII / P00451*	/ reaction / complex
ENSMUSG00000030560	Ctsc / P97821 / cathepsin C / P53634*	/ complex / reaction
ENSMUSG00000041891	Lman1 / Q9D0F3 / Protein ERGIC-53 / P49257* / lectin, mannose binding 1*	/ complex
ENSMUSG00000026579	F5 / O88783 / Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain / P12259* / coagulation factor V*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr