ENSMUSG00000030560


Mus musculus

Features
Gene ID: ENSMUSG00000030560
  
Biological name :Ctsc
  
Synonyms : cathepsin C / Ctsc / P97821
  
Possible biological names infered from orthology : P53634
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 88278085
Gene end: 88310888
  
Corresponding Affymetrix probe sets: 10554789 (MoGene1.0st)   1416382_at (Mouse Genome 430 2.0 Array)   1437939_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032779
Ensembl peptide - ENSMUSP00000119503
Ensembl peptide - ENSMUSP00000147006
NCBI entrez gene - 13032     See in Manteia.
MGI - MGI:109553
RefSeq - NM_001311790
RefSeq - NM_009982
RefSeq Peptide - NP_001298719
RefSeq Peptide - NP_034112
swissprot - Q3UBY5
swissprot - P97821
swissprot - Q3U7T5
swissprot - D3Z220
Ensembl - ENSMUSG00000030560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctscENSDARG00000101334Danio rerio
 CTSCENSGALG00000017239Gallus gallus
 CTSCENSG00000109861Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99JR5 / Tinagl1 / Tubulointerstitial nephritis antigen-like / Q9GZM7* / tubulointerstitial nephritis antigen like 1*ENSMUSG0000002877622
Tinag / tubulointerstitial nephritis antigen / Q9UJW2*ENSMUSG0000003235721
Ctsz / Q9WUU7 / cathepsin Z / Q9UBR2*ENSMUSG0000001625620
Ctsb / P10605 / cathepsin B / P07858*ENSMUSG0000002193920
Ctso / Q8BM88 / cathepsin O / P43234*ENSMUSG0000002801518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR014882  Cathepsin C exclusion
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site
 IPR036496  Cathepsin C, exclusion domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001913 T cell mediated cytotoxicity IGI
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0004252 serine-type endopeptidase activity IMP
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016505 peptidase activator activity involved in apoptotic process IGI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0031404 chloride ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Satb2tm1Rug/Satb2tm1Rug
Genetic Background: Not Specified

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041891 Lman1 / Q9D0F3 / Protein ERGIC-53 / P49257* / lectin, mannose binding 1*  / complex / reaction






 

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