ENSMUSG00000021939


Mus musculus

Features
Gene ID: ENSMUSG00000021939
  
Biological name :Ctsb
  
Synonyms : cathepsin B / Ctsb / P10605
  
Possible biological names infered from orthology : P07858
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 63122462
Gene end: 63145923
  
Corresponding Affymetrix probe sets: 10415844 (MoGene1.0st)   1417490_at (Mouse Genome 430 2.0 Array)   1417491_at (Mouse Genome 430 2.0 Array)   1417492_at (Mouse Genome 430 2.0 Array)   1444987_at (Mouse Genome 430 2.0 Array)   1448732_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006235
NCBI entrez gene - 13030     See in Manteia.
MGI - MGI:88561
RefSeq - NM_007798
RefSeq - XM_017315833
RefSeq Peptide - NP_031824
swissprot - P10605
Ensembl - ENSMUSG00000021939
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctsbaENSDARG00000055120Danio rerio
 ctsbbENSDARG00000101051Danio rerio
 CTSBENSGALG00000030016Gallus gallus
 CTSBENSG00000164733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99JR5 / Tinagl1 / Tubulointerstitial nephritis antigen-like / Q9GZM7* / tubulointerstitial nephritis antigen like 1*ENSMUSG0000002877633
Tinag / tubulointerstitial nephritis antigen / Q9UJW2*ENSMUSG0000003235731
Ctsc / P97821 / cathepsin C / P53634*ENSMUSG0000003056027
Ctsz / Q9WUU7 / cathepsin Z / Q9UBR2*ENSMUSG0000001625621
Ctso / Q8BM88 / cathepsin O / P43234*ENSMUSG0000002801518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR012599  Peptidase C1A, propeptide
 IPR013128  Peptidase C1A
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0046697 decidualization IGI
 biological_processGO:0046718 viral entry into host cell IMP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISO
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043394 proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1atm3Hzo/Cacna1atm3Hzo,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsbtm1Jde
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cacna1atm2.1Kewa/Cacna1atm2.1Kewa,Ctsbtm1Jde/Ctsb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

Allelic Composition: Ctsbtm1Jde/Ctsb+
Genetic Background: NOD.129P2-Ctsbtm1Jde

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se-15THO-I
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

Allelic Composition: Ctsbtm1Jde/Ctsb+
Genetic Background: NOD.129P2-Ctsbtm1Jde

 MP:0004155 resistance to induced pancreatitis "reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nacatm1.1Star/Naca+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6NCrl * DBA/2NCrl

Allelic Composition: Ctsbtm1Jde/Ctsb+
Genetic Background: NOD.129P2-Ctsbtm1Jde

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsktm1Psa/Ctsktm1Psa
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gabra3tm1Dgen/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsztm1Thre/Ctsztm1Thre,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.129P2-Ctsztm1Thre Ctsbtm1Jde Tg(MMTV-PyVT)634Mul

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021939 Ctsb / P10605 / cathepsin B / P07858*  / complex






 

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