ENSG00000164733


Homo sapiens

Features
Gene ID: ENSG00000164733
  
Biological name :CTSB
  
Synonyms : cathepsin B / CTSB / P07858
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 11842524
Gene end: 11869448
  
Corresponding Affymetrix probe sets: 200838_at (Human Genome U133 Plus 2.0 Array)   200839_s_at (Human Genome U133 Plus 2.0 Array)   213274_s_at (Human Genome U133 Plus 2.0 Array)   213275_x_at (Human Genome U133 Plus 2.0 Array)   227961_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433215
Ensembl peptide - ENSP00000432408
Ensembl peptide - ENSP00000433379
Ensembl peptide - ENSP00000473301
Ensembl peptide - ENSP00000436627
Ensembl peptide - ENSP00000436456
Ensembl peptide - ENSP00000436159
Ensembl peptide - ENSP00000436122
Ensembl peptide - ENSP00000436074
Ensembl peptide - ENSP00000435886
Ensembl peptide - ENSP00000435650
Ensembl peptide - ENSP00000435260
Ensembl peptide - ENSP00000435105
Ensembl peptide - ENSP00000435074
Ensembl peptide - ENSP00000434725
Ensembl peptide - ENSP00000434217
Ensembl peptide - ENSP00000433995
Ensembl peptide - ENSP00000433929
Ensembl peptide - ENSP00000342070
Ensembl peptide - ENSP00000345672
Ensembl peptide - ENSP00000409917
Ensembl peptide - ENSP00000431143
Ensembl peptide - ENSP00000431518
Ensembl peptide - ENSP00000432077
Ensembl peptide - ENSP00000432244
NCBI entrez gene - 1508     See in Manteia.
OMIM - 116810
RefSeq - NM_147783
RefSeq - NM_001317237
RefSeq - NM_001908
RefSeq - NM_147780
RefSeq - NM_147781
RefSeq - NM_147782
RefSeq - XM_006716244
RefSeq - XM_006716245
RefSeq - XM_011543812
RefSeq - XM_017013097
RefSeq - XM_017013098
RefSeq - XM_017013099
RefSeq - XM_017013100
RefSeq - XM_017013101
RefSeq Peptide - NP_680092
RefSeq Peptide - NP_680093
RefSeq Peptide - NP_001304166
RefSeq Peptide - NP_001899
RefSeq Peptide - NP_680090
RefSeq Peptide - NP_680091
swissprot - E9PS78
swissprot - E9PR54
swissprot - E9PR00
swissprot - E9PQM1
swissprot - E9PNL5
swissprot - E9PLY3
swissprot - E9PL32
swissprot - E9PKX0
swissprot - E9PKQ7
swissprot - E9PJ67
swissprot - E9PIS1
swissprot - E9PHZ5
swissprot - E9PID0
swissprot - E9PCB3
swissprot - P07858
swissprot - R4GMQ5
swissprot - A0A024R374
swissprot - E9PSG5
Ensembl - ENSG00000164733
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctsbaENSDARG00000055120Danio rerio
 ctsbbENSDARG00000101051Danio rerio
 CTSBENSGALG00000030016Gallus gallus
 CtsbENSMUSG00000021939Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9GZM7 / TINAGL1 / tubulointerstitial nephritis antigen like 1ENSG0000014291033
TINAG / Q9UJW2 / tubulointerstitial nephritis antigenENSG0000013725131
CTSC / P53634 / cathepsin CENSG0000010986129
CTSZ / Q9UBR2 / cathepsin ZENSG0000010116020
CTSO / P43234 / cathepsin OENSG0000025604318


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR012599  Peptidase C1A, propeptide
 IPR013128  Peptidase C1A
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0030574 collagen catabolic process IDA
 biological_processGO:0030855 epithelial cell differentiation IEP
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0036021 endolysosome lumen TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043394 proteoglycan binding IPI


Pathways (from Reactome)
Pathway description
Collagen degradation
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000975 Hyperhidrosis "An abnormally increased perspiration." [HPO:probinson]
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 HP:0010783 Erythema "Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin." [HPO:probinson]
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 HP:0200039 skin pustule "A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells." [HPO:SKOEHLER]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164733 CTSB / P07858 / cathepsin B  / complex






 

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