ENSDARG00000055120


Danio rerio

Features
Gene ID: ENSDARG00000055120
  
Biological name :ctsba
  
Synonyms : cathepsin Ba / ctsba
  
Possible biological names infered from orthology : cathepsin B / CTSB / P07858 / P10605
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 32622931
Gene end: 32631514
  
Corresponding Affymetrix probe sets: Dr.3374.1.S1_at (Zebrafish Array)   Dr.3374.2.S1_at (Zebrafish Array)   NM_213336_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000114825
Ensembl peptide - ENSDARP00000071885
NCBI entrez gene - 406645     See in Manteia.
RefSeq - NM_213336
RefSeq Peptide - NP_998501
swissprot - E9QDX8
swissprot - Q6PH75
ZFIN ID - ZDB-GENE-040426-2650
Ensembl - ENSDARG00000055120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTSBENSGALG00000030016Gallus gallus
 CTSBENSG00000164733Homo sapiens
 CtsbENSMUSG00000021939Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ctsbb / cathepsin Bb / CTSB* / P07858* / P10605* / cathepsin B*ENSDARG0000010105167
tinagl1 / tubulointerstitial nephritis antigen-like 1 / Q99JR5* / Q9GZM7* / Tubulointerstitial nephritis antigen-like *ENSDARG0000006123130
ctsc / cathepsin C / P53634*ENSDARG0000010133429
CABZ01050249.1ENSDARG0000009937621
ctsz / cathepsin Z / Q9UBR2* / Q9WUU7*ENSDARG0000004308120
ctso / cathepsin O / P43234* / Q8BM88*ENSDARG0000005285519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR012599  Peptidase C1A, propeptide
 IPR013128  Peptidase C1A
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0031101 fin regeneration IEP
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0090504 epiboly IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000003 adaxial cell adaxial cell spatial pattern , abnormal
Show

 ZFA:0000071 shield shield decreased amount , abnormal
shield increased distribution , abnormal
Show

 ZFA:0000084 yolk yolk split , abnormal
Show

 ZFA:0000086 EVL EVL epiboly delayed , abnormal
EVL cell increased size , abnormal
EVL cell elongated , abnormal
EVL cell decreased amount , abnormal
Show

 ZFA:0000088 YSL YSL decreased amount , abnormal
Show

 ZFA:0000132 neural plate neural plate spatial pattern , abnormal
Show

 ZFA:0000135 notochord notochord spatial pattern , abnormal
Show

 ZFA:0000155 somite somite spatial pattern , abnormal
Show

 ZFA:0000255 paraxial mesoderm paraxial mesoderm spatial pattern , abnormal
Show

 ZFA:0000279 segmental plate segmental plate spatial pattern , abnormal
Show

 ZFA:0000309 E-YSL E-YSL microtubule absent , abnormal
E-YSL microtubule disorganized , abnormal
E-YSL microtubule decreased amount , abnormal
E-YSL actin cytoskeleton absent , abnormal
E-YSL actin cytoskeleton disorganized , abnormal
E-YSL actin cytoskeleton decreased amount , abnormal
Show

 ZFA:0000711 DEL DEL epiboly delayed , abnormal
Show

 ZFA:0001058 caudal fin caudal fin decreased thickness , abnormal
caudal fin kinked , abnormal
Show

 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
whole organism cytolysis increased occurrence , abnormal
whole organism mislocalised , abnormal
whole organism dorsal region increased distribution , abnormal
whole organism ventral region mislocalised , abnormal
whole organism ventral region decreased amount , abnormal
whole organism ventral region decreased distribution , abnormal
Show

 ZFA:0001175 blastodisc blastodisc decreased amount , abnormal
Show

 ZFA:0007029 hindbrain neural keel hindbrain neural keel decreased distribution , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000101051 ctsbb / cathepsin Bb / CTSB* / P07858* / P10605* / cathepsin B*  / complex
 ENSDARG00000055120 ctsba / cathepsin Ba / CTSB* / P07858* / P10605* / cathepsin B*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr