ENSG00000101160


Homo sapiens

Features
Gene ID: ENSG00000101160
  
Biological name :CTSZ
  
Synonyms : cathepsin Z / CTSZ / Q9UBR2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.32
Gene start: 58995185
Gene end: 59007247
  
Corresponding Affymetrix probe sets: 210042_s_at (Human Genome U133 Plus 2.0 Array)   212562_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000217131
NCBI entrez gene - 1522     See in Manteia.
OMIM - 603169
RefSeq - NM_001336
RefSeq Peptide - NP_001327
swissprot - Q9UBR2
Ensembl - ENSG00000101160
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctszENSDARG00000043081Danio rerio
 CTSZENSGALG00000007462Gallus gallus
 CtszENSMUSG00000016256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSC / P53634 / cathepsin CENSG0000010986131
CTSO / P43234 / cathepsin OENSG0000025604324
Q9GZM7 / TINAGL1 / tubulointerstitial nephritis antigen like 1ENSG0000014291024
TINAG / Q9UJW2 / tubulointerstitial nephritis antigenENSG0000013725123
CTSB / P07858 / cathepsin BENSG0000016473322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR025661  Cysteine peptidase, asparagine active site
 IPR033157  Cathepsin X


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002003 angiotensin maturation TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0010757 negative regulation of plasminogen activation IMP
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:1901214 regulation of neuron death IGI
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle TAS
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099738 cell cortex region IEA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004180 carboxypeptidase activity IMP
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
COPII-mediated vesicle transport
Lysosome Vesicle Biogenesis
Cargo concentration in the ER
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135744 AGT / P01019 / angiotensinogen  / reaction
 ENSG00000074695 LMAN1 / P49257 / lectin, mannose binding 1  / reaction / complex






 

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