ENSG00000135744


Homo sapiens

Features
Gene ID: ENSG00000135744
  
Biological name :AGT
  
Synonyms : AGT / angiotensinogen / P01019
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.2
Gene start: 230702523
Gene end: 230714297
  
Corresponding Affymetrix probe sets: 202834_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355627
NCBI entrez gene - 183     See in Manteia.
OMIM - 106150
RefSeq - NM_000029
RefSeq Peptide - NP_000020
swissprot - B0ZBE2
swissprot - P01019
Ensembl - ENSG00000135744
  
Related genetic diseases (OMIM): 106150 - {Preeclampsia, susceptibility to}
  145500 - {Hypertension, essential, susceptibility to}, 145500
  267430 - Renal tubular dysgenesis, 267430
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agtENSDARG00000016412Danio rerio
 AGTENSGALG00000011117Gallus gallus
 AgtENSMUSG00000031980Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR000227  Angiotensinogen
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR033834  Angiotensinogen serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0001819 positive regulation of cytokine production TAS
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001974 blood vessel remodeling TAS
 biological_processGO:0002003 angiotensin maturation TAS
 biological_processGO:0002016 regulation of blood volume by renin-angiotensin NAS
 biological_processGO:0002018 renin-angiotensin regulation of aldosterone production NAS
 biological_processGO:0002019 regulation of renal output by angiotensin NAS
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0002034 regulation of blood vessel diameter by renin-angiotensin TAS
 biological_processGO:0003014 renal system process IDA
 biological_processGO:0003051 angiotensin-mediated drinking behavior IEA
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IEA
 biological_processGO:0003331 positive regulation of extracellular matrix constituent secretion IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway NAS
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008217 regulation of blood pressure IGI
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IC
 biological_processGO:0010873 positive regulation of cholesterol esterification IDA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014061 regulation of norepinephrine secretion IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014873 response to muscle activity involved in regulation of muscle adaptation ISS
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019229 regulation of vasoconstriction NAS
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0033864 positive regulation of NAD(P)H oxidase activity TAS
 biological_processGO:0034104 negative regulation of tissue remodeling IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling NAS
 biological_processGO:0035813 regulation of renal sodium excretion NAS
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042127 regulation of cell proliferation NAS
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048144 fibroblast proliferation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048659 smooth muscle cell proliferation IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IDA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0051969 regulation of transmission of nerve impulse IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070471 uterine smooth muscle contraction IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901201 regulation of extracellular matrix assembly IGI
 biological_processGO:1903598 positive regulation of gap junction assembly IGI
 biological_processGO:1903779 regulation of cardiac conduction IGI
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1905010 positive regulation of L-lysine import across plasma membrane IEA
 biological_processGO:1905589 positive regulation of L-arginine import across plasma membrane IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process TAS
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity TAS
 molecular_functionGO:0005179 hormone activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0031701 angiotensin receptor binding IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IPI
 molecular_functionGO:0031703 type 2 angiotensin receptor binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Metabolism of Angiotensinogen to Angiotensins
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000079 Abnormality of the urinary tract 
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 HP:0000252 Microcephaly "Microcephaly is a neurodevelopmental disorder in which the circumference of the head is more than two standard deviations smaller than the age- and gender-dependent norm." [HPO:curators]
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 HP:0001562 Oligohydramnios 
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 HP:0002009 Potter facies 
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 HP:0002089 Pulmonary hypoplasia 
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 HP:0002093 Respiratory insufficiency 
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 HP:0002615 Hypotension 
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 HP:0004492 Widely patent fontanels and sutures "An abnormally increased width of the cranial sutures of striking degree." [HPO:curators]
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 HP:0008660 Renotubular dysgenesis 
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 HP:0100519 Anuria "Absence of urine, clinically classified as below 50ml/day." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092009 CMA1 / P23946 / chymase 1  / reaction
 ENSG00000100448 CTSG / P08311 / cathepsin G  / reaction
 ENSG00000101160 CTSZ / Q9UBR2 / cathepsin Z  / reaction
 ENSG00000130234 ACE2 / Q9BYF1 / angiotensin I converting enzyme 2  / reaction
 ENSG00000138792 ENPEP / Q07075 / glutamyl aminopeptidase  / reaction
 ENSG00000148120 C9orf3 / Q8N6M6 / chromosome 9 open reading frame 3  / reaction
 ENSG00000143839 REN / renin / P00797  / reaction
 ENSG00000163751 CPA3 / P15088 / carboxypeptidase A3  / reaction
 ENSG00000159640 ACE / P12821 / angiotensin I converting enzyme  / reaction
 ENSG00000166825 ANPEP / P15144 / alanyl aminopeptidase, membrane  / reaction
 ENSG00000196549 MME / P08473 / membrane metalloendopeptidase  / reaction
 ENSG00000144891 AGTR1 / P30556 / angiotensin II receptor type 1  / reaction / complex
 ENSG00000180772 AGTR2 / P50052 / angiotensin II receptor type 2  / reaction / complex






 

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