ENSG00000138792


Homo sapiens

Features
Gene ID: ENSG00000138792
  
Biological name :ENPEP
  
Synonyms : ENPEP / glutamyl aminopeptidase / Q07075
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q25
Gene start: 110365733
Gene end: 110565285
  
Corresponding Affymetrix probe sets: 204844_at (Human Genome U133 Plus 2.0 Array)   204845_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265162
Ensembl peptide - ENSP00000426265
NCBI entrez gene - 2028     See in Manteia.
OMIM - 138297
RefSeq - XM_017007877
RefSeq - NM_001977
RefSeq Peptide - NP_001968
swissprot - Q07075
swissprot - H0YA67
Ensembl - ENSG00000138792
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 enpepENSDARG00000057064Danio rerio
 ENPEPENSGALG00000031410Gallus gallus
 EnpepENSMUSG00000028024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANPEP / P15144 / alanyl aminopeptidase, membraneENSG0000016682533
ERAP2 / Q6P179 / endoplasmic reticulum aminopeptidase 2ENSG0000016430833
TRHDE / Q9UKU6 / thyrotropin releasing hormone degrading enzymeENSG0000007265732
ERAP1 / Q9NZ08 / endoplasmic reticulum aminopeptidase 1ENSG0000016430732
LNPEP / Q9UIQ6 / leucyl and cystinyl aminopeptidaseENSG0000011344131
NPEPPS / P55786 / aminopeptidase puromycin sensitiveENSG0000014127931
LVRN / Q6Q4G3 / laeverinENSG0000017290127


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033508  Aminopeptidase A
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002003 angiotensin maturation IEA
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin NAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138792 ENPEP / Q07075 / glutamyl aminopeptidase  / complex
 ENSG00000135744 AGT / P01019 / angiotensinogen  / reaction






 

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