ENSMUSG00000028024


Mus musculus

Features
Gene ID: ENSMUSG00000028024
  
Biological name :Enpep
  
Synonyms : Enpep / glutamyl aminopeptidase / P16406
  
Possible biological names infered from orthology : Q07075
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 129269175
Gene end: 129332720
  
Corresponding Affymetrix probe sets: 10502081 (MoGene1.0st)   1448649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029658
Ensembl peptide - ENSMUSP00000128872
Ensembl peptide - ENSMUSP00000129759
NCBI entrez gene - 13809     See in Manteia.
MGI - MGI:106645
RefSeq - NM_007934
RefSeq Peptide - NP_031960
swissprot - Q52JJ6
swissprot - F6YHW2
swissprot - F7B9G4
swissprot - P16406
Ensembl - ENSMUSG00000028024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 enpepENSDARG00000057064Danio rerio
 ENPEPENSGALG00000031410Gallus gallus
 ENPEPENSG00000138792Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Anpep / P97449 / Aminopeptidase N / P15144* / alanyl aminopeptidase, membrane*ENSMUSG0000003906232
Trhde / Q8K093 / Thyrotropin-releasing hormone-degrading ectoenzyme / Q9UKU6* / thyrotropin releasing hormone degrading enzyme*ENSMUSG0000005066332
Erap1 / Q9EQH2 / Endoplasmic reticulum aminopeptidase 1 / Q9NZ08*ENSMUSG0000002158332
Lnpep / Q8C129 / Leucyl-cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*ENSMUSG0000002384531
Npepps / Q11011 / Puromycin-sensitive aminopeptidase / P55786* / aminopeptidase puromycin sensitive*ENSMUSG0000000144130
Lvrn / laeverin / Q6Q4G3*ENSMUSG0000002448126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033508  Aminopeptidase A
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0002003 angiotensin maturation IEA
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0032835 glomerulus development IEP
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0004177 aminopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction
 ENSMUSG00000028024 Enpep / P16406 / glutamyl aminopeptidase / Q07075*  / complex






 

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