ENSMUSG00000031980


Mus musculus

Features
Gene ID: ENSMUSG00000031980
  
Biological name :Agt
  
Synonyms : Agt / angiotensinogen
  
Possible biological names infered from orthology : P01019
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 124556534
Gene end: 124569706
  
Corresponding Affymetrix probe sets: 10582658 (MoGene1.0st)   1423396_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066488
NCBI entrez gene - 11606     See in Manteia.
MGI - MGI:87963
RefSeq - NM_007428
RefSeq Peptide - NP_031454
swissprot - Q3UTR7
Ensembl - ENSMUSG00000031980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agtENSDARG00000016412Danio rerio
 AGTENSGALG00000011117Gallus gallus
 AGTENSG00000135744Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR000227  Angiotensinogen
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002018 renin-angiotensin regulation of aldosterone production IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0003051 angiotensin-mediated drinking behavior IEA
 biological_processGO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IEA
 biological_processGO:0003331 positive regulation of extracellular matrix constituent secretion IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014061 regulation of norepinephrine secretion IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014873 response to muscle activity involved in regulation of muscle adaptation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0034104 negative regulation of tissue remodeling IEA
 biological_processGO:0035813 regulation of renal sodium excretion IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048144 fibroblast proliferation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048659 smooth muscle cell proliferation IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0051969 regulation of transmission of nerve impulse IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070471 uterine smooth muscle contraction IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901201 regulation of extracellular matrix assembly IEA
 biological_processGO:1903598 positive regulation of gap junction assembly IEA
 biological_processGO:1903779 regulation of cardiac conduction IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1905010 positive regulation of L-lysine import across plasma membrane IEA
 biological_processGO:1905589 positive regulation of L-arginine import across plasma membrane IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031701 angiotensin receptor binding IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0031703 type 2 angiotensin receptor binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agttm1Afu/Agt+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu,Agtr2tm1Gsb/Y
Genetic Background: mixed

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu,Agtr2tm1Gsb/Y
Genetic Background: mixed

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002829 abnormal juxtaglomerular apparatus "anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm2Unc/Agttm2Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm2Unc/Agttm2Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005525 increased renal plasma flow rate "greater than the normal volume of plasma passing throught the kidney per unit time" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0005610 increased circulating antidiuretic hormone level "greater than the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Ii/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Agttm1.1Itl/Agttm1.1Itl,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0006375 increased circulating angiotensinogen level "greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm2Unc/Agttm2Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006376 decreased circulating angiotensinogen level "less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Afu/Agt+
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Agttm1Afu/Agttm1Afu,Tg(Fabp4-Agt)2Mte/0
Genetic Background: involves: C57BL/6 * CBA * DBA/2 * ICR

Allelic Composition: Agttm1Unc/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Unc/Agttm2Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1.1Itl/Agttm1.1Itl,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

 MP:0008285 abnormal hippocampus granule cell layer 
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Afu/Agt+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011304 kidney papillary atrophy "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011312 abnormal kidney afferent arteriole morphology "any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011314 abnormal kidney cortex artery morphology "any structural anomaly of the network of tubes that supplies blood to the renal cortex" [MGI:csmith]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011316 abnormal kidney interlobular artery morphology "any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli" [ISBN:0-683-40008-8]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011333 abnormal kidney inner medulla morphology "any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [MGI:csmith, PMID:20614633]
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Allelic Composition: Nkx3-2tm1Tno/Nkx3-2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011422 kidney medulla atrophy "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Agttm1Unc/Agttm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011431 increased urine flow rate "increased volume of urine produced in a specified period of time" [MGI:anna]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011541 decreased urine aldosterone level "a reduced amount of aldosterone in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011543 increased urine antidiuretic hormone level "an increased amount of antidiuretic hormone in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Agttm1Afu/Agttm1Afu
Genetic Background: involves: C57BL/6 * CBA

 MP:0011565 kidney papillary hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx" [MGI:anna]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Agttm1Ii/Agttm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001865 Cpa3 / P15089 / Mast cell carboxypeptidase A / P15088* / carboxypeptidase A3*  / reaction
 ENSMUSG00000020681 Ace / P09470 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 / P12821* / AC113554.1* / angiotensin I converting enzyme*  / reaction
 ENSMUSG00000040314 Ctsg / P28293 / cathepsin G / P08311*  / reaction
 ENSMUSG00000016256 Ctsz / Q9WUU7 / cathepsin Z / Q9UBR2*  / reaction
 ENSMUSG00000022225 Cma1 / P21844 / Chymase / P23946* / chymase 1*  / reaction
 ENSMUSG00000027820 Mme / Q61391 / Neprilysin / P08473* / membrane metalloendopeptidase*  / reaction
 ENSMUSG00000028024 Enpep / P16406 / glutamyl aminopeptidase / Q07075*  / reaction
 ENSMUSG00000054988 Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*  / reaction / complex
 ENSMUSG00000068122 Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*  / reaction / complex
 ENSMUSG00000049115 Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*  / complex / reaction
 ENSMUSG00000070645 Ren1 / P06281 / Mus musculus renin 2 tandem duplication of Ren1 (Ren2), mRNA. / REN* / renin* / P00797*  / reaction
 ENSMUSG00000015405 Ace2 / Q8R0I0 / angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 / Q9BYF1* / angiotensin I converting enzyme 2*  / reaction






 

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