Manteia - Molecule gene

ENSMUSG00000070645

Mus musculus

Features

Gene ID:	ENSMUSG00000070645

Biological name :	Ren1

Synonyms :	Mus musculus renin 2 tandem duplication of Ren1 (Ren2), mRNA. / P06281 / Ren1

Possible biological names infered from orthology :	P00797 / REN / renin

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	E4
Gene start:	133350510
Gene end:	133360325

Corresponding Affymetrix probe sets:	10349922 (MoGene1.0st) 1448975_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000092135 Ensembl peptide - ENSMUSP00000107906 NCBI entrez gene - 19701 See in Manteia. NCBI entrez gene - 19702 See in Manteia. MGI - MGI:97898 RefSeq - NM_031192 RefSeq - NM_031193 RefSeq Peptide - NP_112469 RefSeq Peptide - NP_112470 swissprot - P06281 swissprot - Q9R259 Ensembl - ENSMUSG00000070645

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ren	ENSDARG00000041858	Danio rerio
REN	ENSGALG00000000545	Gallus gallus
REN	ENSG00000143839	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ctsd / P18242 / cathepsin D / P07339* / AC068580.4*	ENSMUSG00000007891	42
Napsa / O09043 / Napsin-A / O96009* / napsin A aspartic peptidase*	ENSMUSG00000002204	41
Ctse / P70269 / cathepsin E / P14091*	ENSMUSG00000004552	39
Pgc / Q9D7R7 / Gastricsin / P20142* / progastricsin*	ENSMUSG00000023987	35
Pga5 / Q9D106 / Pepsin A-5	ENSMUSG00000024738	35
Cym / chymosin	ENSMUSG00000046213	32
AC034099.1 / CTSD* / P07339* / AC068580.4* / cathepsin D*	ENSMUSG00000110040	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR001461	Aspartic peptidase A1 family
IPR001969	Aspartic peptidase, active site
IPR012848	Aspartic peptidase, N-terminal
IPR021109	Aspartic peptidase domain superfamily
IPR033121	Peptidase family A1 domain
IPR034135	Renin-like domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001822	kidney development	IEA
biological_process	GO:0001823	mesonephros development	IEP
biological_process	GO:0002003	angiotensin maturation	IEA
biological_process	GO:0002016	regulation of blood volume by renin-angiotensin	IMP
biological_process	GO:0002018	renin-angiotensin regulation of aldosterone production	IDA
biological_process	GO:0006508	proteolysis	ISO
biological_process	GO:0008217	regulation of blood pressure	IEA
biological_process	GO:0008584	male gonad development	IEP
biological_process	GO:0009755	hormone-mediated signaling pathway	IDA
biological_process	GO:0010033	response to organic substance	IDA
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0035690	cellular response to drug	IEA
biological_process	GO:0035902	response to immobilization stress	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042756	drinking behavior	IMP
biological_process	GO:0043408	regulation of MAPK cascade	IEA
biological_process	GO:0048469	cell maturation	IMP
biological_process	GO:0050435	amyloid-beta metabolic process	IEA
biological_process	GO:0051591	response to cAMP	IEA
biological_process	GO:0070305	response to cGMP	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0045177	apical part of cell	IEA
molecular_function	GO:0004175	endopeptidase activity	IEA
molecular_function	GO:0004190	aspartic-type endopeptidase activity	IBA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0005159	insulin-like growth factor receptor binding	IEA
molecular_function	GO:0008233	peptidase activity	ISO
molecular_function	GO:0016787	hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

Metabolism of Angiotensinogen to Angiotensins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Rp1^tm1Eap/Rp1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Rp1^tm1Eap/Rp1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Gna12^tm1Citb/Gna12^tm1Citb,Gna13^tm2.1Soff/Gna13^tm2.1Soff Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N
MP:0001426	polydipsia	"excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^tm1Mim/Grid2^tm1Mim Genetic Background: involves: C57BL/6 * CBA
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Rp1^tm1Eap/Rp1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001596	hypotension	"sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Gna12^tm1Citb/Gna12^tm1Citb,Gna13^tm2.1Soff/Gna13^tm2.1Soff Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Rp1^tm1Eap/Rp1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Rp1^tm1Eap/Rp1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Gna12^tm1Citb/Gna12^tm1Citb,Gna13^tm2.1Soff/Gna13^tm2.1Soff Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N
MP:0002666	increased circulating aldosterone level	"increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0002667	decreased circulating aldosterone level	"decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002829	abnormal juxtaglomerular apparatus	"anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA
MP:0002843	decreased blood pressure	"decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1Gom/Ren1^tm1Gom Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd
MP:0002988	decreased urine osmolarity	"reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw,Ren1^tm2(cre)Gom/Ren1⁺ Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0003014	abnormal kidney medulla morphology	"anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003026	decreased vascular smooth muscle contraction	"reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0003353	decreased circulating renin level	"reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm3Gom/Ren1⁺ Genetic Background: 129S6/SvEvTac-Ren1^tm3Gom Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1Gom/Ren1^tm1Gom Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw,Ren1^tm2(cre)Gom/Ren1⁺ Genetic Background: involves: 129S6/SvEvTac * Black Swiss
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004184	abnormal baroreceptor physiology	"anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0004876	decreased mean arterial blood pressure	"decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ren1^tm1Bjm/Ren1^tm1Bjm Genetic Background: B6(Cg)-Ren1^tm1Bjm Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw,Ren1^tm2(cre)Gom/Ren1⁺ Genetic Background: involves: 129S6/SvEvTac * Black Swiss Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0004970	kidney atrophy	"wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0005264	glomerulosclerosis	"hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rp1^tm1Eap/Rp1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005489	vascular smooth muscle cell hyperplasia	"increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]	Show Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA
MP:0005528	decreased glomerular filtration rate	"less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Gna12^tm1Citb/Gna12^tm1Citb,Gna13^tm2.1Soff/Gna13^tm2.1Soff Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw,Ren1^tm2(cre)Gom/Ren1⁺ Genetic Background: involves: 129S6/SvEvTac * Black Swiss
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh Allelic Composition: Ren1^tm1Bjm/Ren1^tm1Bjm Genetic Background: B6(Cg)-Ren1^tm1Bjm
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0005581	abnormal renin activity	"alterated ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw,Ren1^tm2(cre)Gom/Ren1⁺ Genetic Background: involves: 129S6/SvEvTac * Black Swiss
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006263	decreased diastolic blood pressure	"abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Ren1^tm1Bjm/Ren1^tm1Bjm Genetic Background: B6(Cg)-Ren1^tm1Bjm Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA
MP:0006264	decreased systolic blood pressure	"abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Ren1^tm1Bjm/Ren1^tm1Bjm Genetic Background: B6(Cg)-Ren1^tm1Bjm Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig Genetic Background: involves: C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011294	renal glomerulus hypertrophy	"increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011299	abnormal macula densa morphology	"any structural anomaly of the specialized group of densely packed epithelial cells marking the origin of the convoluted portion of the distal tubule of a nephron, in contact with the afferent arteriole of the renal corpuscle and contiguous with the juxtaglomerular cells; these cells are tall, thin and columnar, have prominent nuclei, and act as sensors of solute concentration and flow of tubular fluid" [MGI:anna]	Show Allelic Composition: Ren1^tm1Bjm/Ren1^tm1Bjm Genetic Background: B6(Cg)-Ren1^tm1Bjm Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd
MP:0011300	abnormal juxtaglomerular cell morphology	"any structural anomaly of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa; J-G cells are distinguished by their granulated cytoplasm and play a critical role in the renin-angiotensin system and thus in renal autoregulation" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm3Gom/Ren1⁺ Genetic Background: 129S6/SvEvTac-Ren1^tm3Gom Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Ren1^tm1Gom/Ren1^tm1Gom Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs Genetic Background: involves: 129P2/OlaHsd
MP:0011304	kidney papillary atrophy	"acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011312	abnormal kidney afferent arteriole morphology	"any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011316	abnormal kidney interlobular artery morphology	"any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli" [ISBN:0-683-40008-8]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011346	renal tubule atrophy	"acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011352	proximal convoluted tubule brush border loss	"attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011363	renal glomerulus atrophy	"acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011377	renal glomerulus fibrosis	"formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011422	kidney medulla atrophy	"acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011423	kidney cortex atrophy	"acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011534	granular kidney	"a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [MGI:anna]	Show Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0011563	increased urine prostaglandin level	"a greater amount of any prostaglandin in the urine compared to the normal state" [MGI:anna]	Show Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw,Ren1^tm2(cre)Gom/Ren1⁺ Genetic Background: involves: 129S6/SvEvTac * Black Swiss
MP:0011565	kidney papillary hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx" [MGI:anna]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh
MP:0012551	metabolic acidosis	"decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]	Show Allelic Composition: Ren1^tm1Tkh/Ren1^tm1Tkh Genetic Background: C57BL/6-Ren1^tm1Tkh

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031007	Q9CYN9 / Atp6ap2 / Renin receptor / O75787* / ATPase H+ transporting accessory protein 2*	/ complex
ENSMUSG00000031980	Agt / angiotensinogen / P01019*	/ reaction

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