ENSMUSG00000002204


Mus musculus

Features
Gene ID: ENSMUSG00000002204
  
Biological name :Napsa
  
Synonyms : Napsa / Napsin-A / O09043
  
Possible biological names infered from orthology : napsin A aspartic peptidase / O96009
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44572380
Gene end: 44586862
  
Corresponding Affymetrix probe sets: 10552697 (MoGene1.0st)   1423590_at (Mouse Genome 430 2.0 Array)   1430744_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146791
Ensembl peptide - ENSMUSP00000002274
NCBI entrez gene - 16541     See in Manteia.
MGI - MGI:109365
RefSeq - NM_008437
RefSeq Peptide - NP_032463
swissprot - A0A140LIE6
swissprot - O09043
swissprot - Q3U7H1
Ensembl - ENSMUSG00000002204
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:63831ENSDARG00000009313Danio rerio
 NAPSAENSG00000131400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsd / P18242 / cathepsin D / P07339* / AC068580.4*ENSMUSG0000000789144
Ctse / P70269 / cathepsin E / P14091*ENSMUSG0000000455242
Ren1 / P06281 / Mus musculus renin 2 tandem duplication of Ren1 (Ren2), mRNA. / REN* / renin* / P00797*ENSMUSG0000007064539
Pgc / Q9D7R7 / Gastricsin / P20142* / progastricsin*ENSMUSG0000002398736
Cym / chymosinENSMUSG0000004621333
Pga5 / Q9D106 / Pepsin A-5 ENSMUSG0000002473833
AC034099.1 / CTSD* / P07339* / AC068580.4* / cathepsin D*ENSMUSG0000011004028


Protein motifs (from Interpro)
Interpro ID Name
 IPR001461  Aspartic peptidase A1 family
 IPR001969  Aspartic peptidase, active site
 IPR021109  Aspartic peptidase domain superfamily
 IPR033121  Peptidase family A1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006914 autophagy IBA
 biological_processGO:0030163 protein catabolic process IBA
 biological_processGO:0033619 membrane protein proteolysis IMP
 biological_processGO:0043129 surfactant homeostasis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0097208 alveolar lamellar body IDA
 molecular_functionGO:0004175 endopeptidase activity IMP
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022097 Sftpc / surfactant associated protein C / P11686* / surfactant protein C*  / reaction
 ENSMUSG00000056370 Sftpb / surfactant associated protein B / P07988* / surfactant protein B*  / reaction






 

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