ENSG00000131400


Homo sapiens

Features
Gene ID: ENSG00000131400
  
Biological name :NAPSA
  
Synonyms : NAPSA / napsin A aspartic peptidase / O96009
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 50358477
Gene end: 50365830
  
Corresponding Affymetrix probe sets: 223806_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469763
Ensembl peptide - ENSP00000253719
Ensembl peptide - ENSP00000469061
NCBI entrez gene - 9476     See in Manteia.
OMIM - 605631
RefSeq - XM_017027512
RefSeq - NM_004851
RefSeq - XM_011527540
RefSeq Peptide - NP_004842
swissprot - O96009
swissprot - M0QXC5
swissprot - A0A0B4J2A8
Ensembl - ENSG00000131400
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:63831ENSDARG00000009313Danio rerio
 NapsaENSMUSG00000002204Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSD / P07339 / cathepsin DENSG0000011798445
CTSE / P14091 / cathepsin EENSG0000019618841
AC068580.4ENSG0000025064440
REN / renin / P00797ENSG0000014383939
PGA5 / P0DJD9 / pepsinogen 5, group I (pepsinogen A)ENSG0000025671338
PGA4 / P0DJD7 / pepsinogen 4, group I (pepsinogen A)ENSG0000022918338
PGA3 / P0DJD8 / pepsinogen 3, group I (pepsinogen A)ENSG0000022985938
PGC / P20142 / progastricsinENSG0000009608835


Protein motifs (from Interpro)
Interpro ID Name
 IPR001461  Aspartic peptidase A1 family
 IPR001969  Aspartic peptidase, active site
 IPR021109  Aspartic peptidase domain superfamily
 IPR033121  Peptidase family A1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006914 autophagy IBA
 biological_processGO:0030163 protein catabolic process IBA
 biological_processGO:0033619 membrane protein proteolysis IDA
 biological_processGO:0043129 surfactant homeostasis IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097208 alveolar lamellar body IDA
 cellular_componentGO:0097486 multivesicular body lumen TAS
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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