| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0001190 | reddish skin | "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
|
| MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0001222 | epidermal hyperplasia | "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0001246 | mixed cellular infiltration to dermis | "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J
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| MP:0002376 | abnormal dendritic cell physiology | "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808] |
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J
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| MP:0002455 | abnormal dendritic cell antigen presentation | "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Prkntm1Shn/Prkntm1Shn
Genetic Background: B6.129S4-Prkntm1Shn/J
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| MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Ctsetm1Kjy/Ctse+
Genetic Background: involves: C57BL/6
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| MP:0005011 | increased eosinophil count | "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0005091 | increased double-positive T cell count | "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0008635 | increased circulating interleukin-18 level | "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0008641 | increased circulating interleukin-1 beta level | "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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| MP:0008702 | increased interleukin-5 secretion | "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: Nptx2tm1Mspn/Nptx2tm1Mspn
Genetic Background: involves: 129 * C57BL/6
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