MP:0000136 | abnormal microglial cell morphology | "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0000427 | abnormal hair cycle | "aberrant growth or asynchronous timing of the hair growth " [J:65302] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0000703 | abnormal thymus morphology | "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
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MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0000811 | hippocampal neuron degeneration | "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0001648 | abnormal apoptosis | "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0001835 | abnormal antigen presentation | "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0001967 | deafness | "inability to hear" [J:57651] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0002001 | blindness | "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
Allelic Composition: Ctsdtm1b(EUCOMM)Wtsi/Ctsdtm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ctsdtm1b(EUCOMM)Wtsi/Ics
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MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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MP:0002357 | abnormal spleen white pulp morphology | "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0002581 | abnormal ileum morphology | "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0002826 | tonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0002855 | abnormal cochlear ganglion morphology | "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0003225 | axonal dystrophy | "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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MP:0003382 | straub tail | "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi
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MP:0003644 | thymus atrophy | "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0005048 | thrombosis | "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0005059 | lysosomal protein accumulation | "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0008470 | abnormal spleen B cell follicle morphology | "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967] |
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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MP:0010783 | abnormal stomach wall morphology | "the layered structure that makes up the stomach, consisting of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0011083 | complete lethality at weaning | "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
Allelic Composition: Ctsdtm1b(EUCOMM)Wtsi/Ctsdtm1b(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ctsdtm1b(EUCOMM)Wtsi/Ics
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Ctsdm1J/Ctsdm1J Genetic Background: C3HeB/FeJ-Ctsdm1J/GrsrJ
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MP:0014078 | small intestinal villus atrophy | "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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MP:0014082 | decreased small intestinal villus height | "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353] |
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Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
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