ENSDARG00000057698


Danio rerio

Features
Gene ID: ENSDARG00000057698
  
Biological name :ctsd
  
Synonyms : cathepsin D / ctsd
  
Possible biological names infered from orthology : AC034099.1 / AC068580.4 / P07339 / P18242
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 16133595
Gene end: 16146081
  
Corresponding Affymetrix probe sets: Dr.19238.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074872
Ensembl peptide - ENSDARP00000124482
NCBI entrez gene - 65225     See in Manteia.
swissprot - F8W366
swissprot - Q8AWD9
ZFIN ID - ZDB-GENE-010131-8
Ensembl - ENSDARG00000057698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTSDENSGALG00000006613Gallus gallus
 AC068580.4ENSG00000250644Homo sapiens
 CTSDENSG00000117984Homo sapiens
 AC034099.1ENSMUSG00000110040Mus musculus
 CtsdENSMUSG00000007891Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:63831 / NAPSA* / O09043* / O96009* / Napsin-A * / napsin A aspartic peptidase*ENSDARG0000000931360
ren / renin / Ren1* / P06281* / P00797* / Mus musculus renin 2 tandem duplication of Ren1 (Ren2), mRNA.*ENSDARG0000004185848
PGA3 / pepsinogen 3, group I (pepsinogen A) / PGC* / PGA4* / CTSE* / PGA5* / P20142* / P0DJD9* / P0DJD8* / P0DJD7* / P14091* / cathepsin E* / progastricsin* / pepsinogen 5, group I (pepsino...ENSDARG0000009982432


Protein motifs (from Interpro)
Interpro ID Name
 IPR001461  Aspartic peptidase A1 family
 IPR001969  Aspartic peptidase, active site
 IPR012848  Aspartic peptidase, N-terminal
 IPR021109  Aspartic peptidase domain superfamily
 IPR033121  Peptidase family A1 domain
 IPR033144  Cathepsin D


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003406 retinal pigment epithelium development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006914 autophagy IBA
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0030163 protein catabolic process IBA
 biological_processGO:0061061 muscle structure development IMP
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Metabolism of Angiotensinogen to Angiotensins
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium absent , abnormal
Show

 ZFA:0000152 retina retina lacks all parts of type retinal pigmented epithelium microvillus, abnormal
Show

 ZFA:0000368 integument integument increased pigmentation , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal decreased size , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature muscle morphology , abnormal
trunk musculature muscle cell disorganized , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism viability , abnormal
whole organism bent , abnormal
whole organism dead , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
Show

 ZFA:0005145 muscle muscle myoseptum decreased thickness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000057698 ctsd / cathepsin D / P07339* / P18242* / AC034099.1* / AC068580.4*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr