ENSMUSG00000022097


Mus musculus

Features
Gene ID: ENSMUSG00000022097
  
Biological name :Sftpc
  
Synonyms : Sftpc / surfactant associated protein C
  
Possible biological names infered from orthology : P11686 / surfactant protein C
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D2
Gene start: 70520949
Gene end: 70524081
  
Corresponding Affymetrix probe sets: 10421387 (MoGene1.0st)   1418639_at (Mouse Genome 430 2.0 Array)   1438290_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022692
NCBI entrez gene - 20389     See in Manteia.
MGI - MGI:109517
RefSeq - NM_011359
RefSeq Peptide - NP_035489
swissprot - Q6P8P8
Ensembl - ENSMUSG00000022097
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SFTPCENSG00000168484Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001729  Pulmonary surfactant-associated protein C
 IPR007084  BRICHOS domain
 IPR015091  Surfactant protein C, N-terminal propeptide
 IPR018051  Surfactant-associated polypeptide, palmitoylation site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007585 respiratory gaseous exchange IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001443 poor grooming "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1(cre/ERT2)Blh/Sftpc+,Trp53tm5Tyj/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

 MP:0010891 increased alveolar lamellar body number "greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010943 abnormal bronchus epithelium morphology "any structural anomaly of the epithelial layer of the bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ece1tm1Reh/Ece1tm1Reh,Ece2tm1Ywa/Ece2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010950 abnormal lung hysteresivity "anomaly in the lung tissue property defined as the ratio of dissipated energy to stored energy over a respiratory cycle; it can be measured as the area enclosed by a pressure-volume loop of the lung, and is dependent on composition and microstructure of the tissue components such as the elastic connective tissue" [PMID:2606848]
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Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002204 Napsa / O09043 / Napsin-A / O96009* / napsin A aspartic peptidase*  / reaction
 ENSMUSG00000032359 Ctsh / P49935 / cathepsin H / P09668*  / reaction






 

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