Manteia

ENSMUSG00000032359

Mus musculus

Features

Gene ID:	ENSMUSG00000032359

Biological name :	Ctsh

Synonyms :	cathepsin H / Ctsh / P49935

Possible biological names infered from orthology :	P09668

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	E3.1
Gene start:	90054152
Gene end:	90076089

Corresponding Affymetrix probe sets:	10587733 (MoGene1.0st) 1418365_at (Mouse Genome 430 2.0 Array) 1443814_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000034915 Ensembl peptide - ENSMUSP00000140437 Ensembl peptide - ENSMUSP00000122108 Ensembl peptide - ENSMUSP00000117599 Ensembl peptide - ENSMUSP00000114427 NCBI entrez gene - 13036 See in Manteia. MGI - MGI:107285 RefSeq - XM_011242660 RefSeq - NM_001312649 RefSeq - NM_007801 RefSeq Peptide - NP_001299578 RefSeq Peptide - NP_031827 swissprot - D7UEQ9 swissprot - D3Z437 swissprot - A0A087WR20 swissprot - D3YVI3 swissprot - P49935 Ensembl - ENSMUSG00000032359

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ctsh	ENSDARG00000041108	Danio rerio
CTSH	ENSGALG00000033557	Gallus gallus
CTSH	ENSG00000103811	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*	ENSMUSG00000021477	39
Ctsk / P55097 / cathepsin K / P43235*	ENSMUSG00000028111	38
Ctsll3 / cathepsin L-like 3 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000056728	36
Ctss / O70370 / cathepsin S / P25774*	ENSMUSG00000038642	36
Q80UB0 / 4930486L24Rik / Testin-2 Testin-1 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000050345	35
BC051665 / cDNA sequence BC051665 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000042243	35
Cts6 / cathepsin 6 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000021441	35
Ctsj / Q9R014 / cathepsin J / CTSL* / P07711* / cathepsin L*	ENSMUSG00000055298	35
Ctsr / Q9JIA9 / cathepsin R / CTSL* / P07711* / cathepsin L*	ENSMUSG00000055679	34
Ctsf / Q9R013 / cathepsin F / Q9UBX1*	ENSMUSG00000083282	34
Ctsm / cathepsin M / CTSL* / P07711* / cathepsin L*	ENSMUSG00000074871	34
Cts8 / Q9JI81 / cathepsin 8 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000057446	33
Ctsq / cathepsin Q / CTSL* / P07711* / cathepsin L*	ENSMUSG00000021439	33
Cts7 / Q91ZF2 / cathepsin 7 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000021440	32
Cts3 / cathepsin 3 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000074870	32
Ctsw / P56203 / cathepsin W / P56202*	ENSMUSG00000024910	27
CT030254.2 / CTSL* / P07711* / cathepsin L*	ENSMUSG00000114904	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000169	Cysteine peptidase, cysteine active site
IPR000668	Peptidase C1A, papain C-terminal
IPR013128	Peptidase C1A
IPR013201	Cathepsin propeptide inhibitor domain (I29)
IPR025660	Cysteine peptidase, histidine active site
IPR025661	Cysteine peptidase, asparagine active site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001656	metanephros development	ISS
biological_process	GO:0001913	T cell mediated cytotoxicity	IGI
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0002764	immune response-regulating signaling pathway	IEA
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010634	positive regulation of epithelial cell migration	IMP
biological_process	GO:0010813	neuropeptide catabolic process	IEA
biological_process	GO:0010815	bradykinin catabolic process	IEA
biological_process	GO:0010952	positive regulation of peptidase activity	IGI
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0031638	zymogen activation	IEA
biological_process	GO:0031648	protein destabilization	IEA
biological_process	GO:0032526	response to retinoic acid	IDA
biological_process	GO:0033619	membrane protein proteolysis	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IMP
biological_process	GO:0043129	surfactant homeostasis	IEA
biological_process	GO:0045766	positive regulation of angiogenesis	IMP
biological_process	GO:0051603	proteolysis involved in cellular protein catabolic process	IBA
biological_process	GO:0060448	dichotomous subdivision of terminal units involved in lung branching	IMP
biological_process	GO:0070371	ERK1 and ERK2 cascade	IEA
biological_process	GO:0097067	cellular response to thyroid hormone stimulus	IEA
biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005764	lysosome	IBA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
cellular_component	GO:0097208	alveolar lamellar body	IEA
molecular_function	GO:0004175	endopeptidase activity	IEA
molecular_function	GO:0004177	aminopeptidase activity	IEA
molecular_function	GO:0004197	cysteine-type endopeptidase activity	IEA
molecular_function	GO:0004252	serine-type endopeptidase activity	IMP
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008234	cysteine-type peptidase activity	IEA
molecular_function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IGI
molecular_function	GO:0016505	peptidase activator activity involved in apoptotic process	IGI
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0030108	HLA-A specific activating MHC class I receptor activity	IEA
molecular_function	GO:0070324	thyroid hormone binding	IEA

Pathways (from Reactome)

Pathway description

MHC class II antigen presentation

Surfactant metabolism

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccr2^{tm1.1(CCR2)Rodb}/Ccr2^{tm1.1(CCR2)Rodb} Genetic Background: involves: C57BL/6
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hprt^{tm1(tetO-Runx1,-EGFP)Enk}/Hprt⁺,Sox10^tm2(rtTA)Weg/Sox10⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hprt^{tm1(tetO-Runx1,-EGFP)Enk}/Hprt⁺,Sox10^tm2(rtTA)Weg/Sox10⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0010993	decreased surfactant secretion	"decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hprt^{tm1(tetO-Runx1,-EGFP)Enk}/Hprt⁺,Sox10^tm2(rtTA)Weg/Sox10⁺ Genetic Background: involves: 129P2/OlaHsd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000022097	Sftpc / surfactant associated protein C / P11686* / surfactant protein C*	/ reaction
ENSMUSG00000056370	Sftpb / surfactant associated protein B / P07988* / surfactant protein B*	/ reaction
ENSMUSG00000032359	Ctsh / P49935 / cathepsin H / P09668*	/ complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr