ENSMUSG00000021477


Mus musculus

Features
Gene ID: ENSMUSG00000021477
  
Biological name :Ctsl
  
Synonyms : cathepsin L / Ctsl / P06797
  
Possible biological names infered from orthology : cathepsin V / CTSV / O60911
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B3
Gene start: 64359337
Gene end: 64370890
  
Corresponding Affymetrix probe sets: 10410124 (MoGene1.0st)   1451310_a_at (Mouse Genome 430 2.0 Array)   1457724_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152169
Ensembl peptide - ENSMUSP00000152819
Ensembl peptide - ENSMUSP00000152551
Ensembl peptide - ENSMUSP00000152497
Ensembl peptide - ENSMUSP00000152357
Ensembl peptide - ENSMUSP00000021933
NCBI entrez gene - 13039     See in Manteia.
MGI - MGI:88564
RefSeq - XM_006517080
RefSeq - NM_009984
RefSeq Peptide - NP_034114
swissprot - A0A1Y7VNQ4
swissprot - A0A1Y7VP49
swissprot - A0A1Y7VJC1
swissprot - P06797
swissprot - Q543M3
swissprot - A0A1Y7VNM3
Ensembl - ENSMUSG00000021477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctslbENSDARG00000039173Danio rerio
 ctslbENSDARG00000074306Danio rerio
 ctsllENSDARG00000011701Danio rerio
 MGC174155ENSDARG00000095072Danio rerio
 si:dkey-239j18.2ENSDARG00000095254Danio rerio
 si:dkey-239j18.3ENSDARG00000089806Danio rerio
 si:dkey-269i1.4ENSDARG00000095744Danio rerio
 si:dkey-269i1.4ENSDARG00000100833Danio rerio
 si:dkey-26g8.4ENSDARG00000087651Danio rerio
 si:dkey-26g8.5ENSDARG00000089750Danio rerio
 zgc:174153ENSDARG00000079376Danio rerio
 zgc:174154ENSDARG00000075527Danio rerio
 zgc:174855ENSDARG00000094559Danio rerio
 CTSVENSGALG00000012610Gallus gallus
 CTSVENSG00000136943Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BC051665 / cDNA sequence BC051665 / CTSL* / P07711* / cathepsin L*ENSMUSG0000004224361
Ctsll3 / cathepsin L-like 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005672860
Q80UB0 / 4930486L24Rik / Testin-2 Testin-1 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005034559
Ctsm / cathepsin M / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487156
Ctsj / Q9R014 / cathepsin J / CTSL* / P07711* / cathepsin L*ENSMUSG0000005529853
Cts6 / cathepsin 6 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144152
Cts8 / Q9JI81 / cathepsin 8 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005744652
Ctsr / Q9JIA9 / cathepsin R / CTSL* / P07711* / cathepsin L*ENSMUSG0000005567951
Cts3 / cathepsin 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487051
Ctss / O70370 / cathepsin S / P25774*ENSMUSG0000003864249
Cts7 / Q91ZF2 / cathepsin 7 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144049
Ctsq / cathepsin Q / CTSL* / P07711* / cathepsin L*ENSMUSG0000002143948
Ctsk / P55097 / cathepsin K / P43235*ENSMUSG0000002811147
Ctsh / P49935 / cathepsin H / P09668*ENSMUSG0000003235939
Ctsf / Q9R013 / cathepsin F / Q9UBX1*ENSMUSG0000008328238
Ctsw / P56203 / cathepsin W / P56202*ENSMUSG0000002491030
CT030254.2 / CTSL* / P07711* / cathepsin L*ENSMUSG0000011490420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISS
 biological_processGO:0007154 cell communication ISS
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0008584 male gonad development ISS
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0009749 response to glucose ISS
 biological_processGO:0010259 multicellular organism aging ISS
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0014070 response to organic cyclic compound ISS
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0016540 protein autoprocessing IDA
 biological_processGO:0021675 nerve development ISS
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0034698 response to gonadotropin ISS
 biological_processGO:0046697 decidualization ISS
 biological_processGO:0048102 autophagic cell death ISS
 biological_processGO:0051384 response to glucocorticoid ISS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 biological_processGO:0060008 Sertoli cell differentiation ISS
 biological_processGO:1990834 response to odorant IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IGI
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005773 vacuole ISS
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0009897 external side of plasma membrane ISS
 cellular_componentGO:0030141 secretory granule ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0045177 apical part of cell ISS
 molecular_functionGO:0004177 aminopeptidase activity ISS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016807 cysteine-type carboxypeptidase activity IDA
 molecular_functionGO:0030984 kininogen binding IEA
 molecular_functionGO:0042277 peptide binding ISS
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsltm1Alpk/Ctsl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsltm1Alpk/Ctsl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000376 folliculitis "inflammatory reaction in hair follicles " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

Allelic Composition: Ctsltm1.1Thre/Ctsltm1.1Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Ctsltm1.2Thre/Ctsltm1.2Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

Allelic Composition: Ctsltm1.2Thre/Ctsltm1.2Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctsltm1.2Thre/Ctsltm1.2Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001283 sparse vibrissae "few and widely spaced whiskers" [J:65302]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednratm1Ywa/Ednratm1Ywa,Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsltm1.2Thre/Ctsltm1.2Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: NOD.129P2-Ctsltm1Cptr

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ift172tm1.2Rama/Ift172tm1.2Rama
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: B6.129P2-Ctsltm1Alpk

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003865 lymph node inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: NOD.129P2-Ctsltm1Cptr

 MP:0004085 abnormal heartbeat "anomaly in the appearance of regularly spaced contractions of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ift172tm1.2Rama/Ift172tm1.2Rama
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Ctsltm1Cptr/Ctsl+
Genetic Background: NOD.129P2-Ctsltm1Cptr

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhtm1Bhr/Amhtm1Bhr,ArTfm/Y
Genetic Background: either: (involves 129P3/J * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: NOD.129P2-Ctsltm1Cptr

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsktm1Psa/Ctsktm1Psa,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0006033 abnormal external auditory canal "malformation of the canal that connects the outer and middle ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0006045 mitral valve insufficiency "the mitral valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Alpk/Ctsltm1Alpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: NOD.129P2-Ctsltm1Cptr

Allelic Composition: Ctsltm1.2Thre/Ctsltm1.2Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008726 enlarged left atrium "increased size of the left upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsltm1.2Thre/Ctsltm1.2Thre
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009600 hypergranulosis "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

 MP:0010202 focal dorsal hair loss "focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:Sanger_Karp "Submission from Natasha Karp"]
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Allelic Composition: Ctsltm1Alpk/Ctsl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0010688 hair follicle outer rooth sheath hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Csktm2Sia/Csktm2Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * DBA/2)

Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctsbtm1Jde/Ctsbtm1Jde,Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0011223 dilated lymph node medullary sinus "the luminal space of the lymph node medulla is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0011919 abnormal R wave "any anomaly in the R wave which represents ventricular depolarization and corresponds to electrical impulses rather than mechanical ventricular contractions; irregular or multiple R waves may indicate arrhythmia and the shape of the R waves may indicate ventricular problems" [MPD:Molly]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd

 MP:0013251 dental pulp necrosis "morphological changes resulting from pathological death of dental pulp tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0013593 enlarged thymus cortex "increased size of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes" [ISBN:0-683-40008-8, MGI:Anna]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0030515 periodontal ligament necrosis "morphological changes resulting from pathological death of periodontal ligament tissue; usually due to irreversible damage" [MGI:anna]
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Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0030571 dilated piliary canal "stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [MGI:anna, PMID:11171393]
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Allelic Composition: Ctsltm1Cptr/Ctsltm1Cptr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018623 Mmp7 / matrix metallopeptidase 7 / P09237*  / reaction
 ENSMUSG00000048775 Q8CDC0 / Serpinb13 / Serpin B13 / Q9UIV8* / serpin family B member 13*  / reaction / complex
 ENSMUSG00000050578 Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*  / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr