ENSDARG00000074306


Danio rerio

Features
Gene ID: ENSDARG00000074306
  
Biological name :ctslb
  
Synonyms : cathepsin Lb / ctslb
  
Possible biological names infered from orthology : 4930486L24Rik / BC051665 / cathepsin 3 / cathepsin 6 / cathepsin 7 / cathepsin 8 / cathepsin J / cathepsin L / cathepsin L-like 3 / cathepsin M / cathepsin Q / cathepsin R / cathepsin V / cDNA sequence BC051665 / CT030254.2 / Cts3 / Cts6 / Cts7 / Cts8 / Ctsj / CTSL / Ctsll3 / Ctsm / Ctsq / Ctsr / CTSV / O60911 / P06797 / P07711 / Q80UB0 / Q91ZF2 / Q9JI81 / Q9JIA9 / Q9R014 / Testin-2 Testin-1
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 16691584
Gene end: 16694092
  
Corresponding Affymetrix probe sets: Dr.25683.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000047915
NCBI entrez gene - 564979     See in Manteia.
RefSeq - NM_001105115
RefSeq Peptide - NP_001098585
swissprot - A7MCR7
ZFIN ID - ZDB-GENE-980526-285
Ensembl - ENSDARG00000074306
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTSVENSGALG00000012610Gallus gallus
 CTSLENSG00000135047Homo sapiens
 CTSVENSG00000136943Homo sapiens
 BC051665ENSMUSG00000042243Mus musculus
 CT030254.2ENSMUSG00000114904Mus musculus
 Cts3ENSMUSG00000074870Mus musculus
 Cts6ENSMUSG00000021441Mus musculus
 Cts7ENSMUSG00000021440Mus musculus
 Cts8ENSMUSG00000057446Mus musculus
 CtsjENSMUSG00000055298Mus musculus
 CtslENSMUSG00000021477Mus musculus
 Ctsll3ENSMUSG00000056728Mus musculus
 CtsmENSMUSG00000074871Mus musculus
 CtsqENSMUSG00000021439Mus musculus
 CtsrENSMUSG00000055679Mus musculus
 Q80UB0ENSMUSG00000050345Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-269i1.4 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / B...ENSDARG0000009574499
si:dkey-26g8.4 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / BC...ENSDARG0000008765199
si:dkey-239j18.3 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / ...ENSDARG0000008980699
ctslb / cathepsin Lb / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81...ENSDARG0000003917398
si:dkey-269i1.4 / CTSL* / CTSV* / O60911* / P07711* / cathepsin V* / cathepsin L*ENSDARG0000010083398
MGC174155 / Cathepsin L1-like / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / Cts3* / CTSV* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0*...ENSDARG0000009507298
si:dkey-26g8.5 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / BC...ENSDARG0000008975097
zgc:174153 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000007937697
si:dkey-239j18.2 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / ...ENSDARG0000009525496
zgc:174154 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000007552796
zgc:174855 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000009455996
ctsll / cathepsin L, like / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q...ENSDARG0000001170176
ctsla / cathepsin LaENSDARG0000000783668
ctsl.1 / cathepsin L.1ENSDARG0000000390250
ctsk / cathepsin K / P43235* / P55097*ENSDARG0000004025146
ctss2.2 / cathepsin S, ortholog 2, tandem duplicate 2 / CTSS* / O70370* / P25774* / cathepsin S*ENSDARG0000001377146
ctss2.1 / cathepsin S, ortholog2, tandem duplicate 1 / CTSS* / O70370* / P25774* / cathepsin S*ENSDARG0000007465645
cts12 / cathepsin 12ENSDARG0000004275344
ctss1 / cathepsin S, ortholog 1ENSDARG0000003694041
zgc:110239ENSDARG0000007766440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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