ENSG00000135047


Homo sapiens

Features
Gene ID: ENSG00000135047
  
Biological name :CTSL
  
Synonyms : cathepsin L / CTSL / P07711
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.33
Gene start: 87725519
Gene end: 87731393
  
Corresponding Affymetrix probe sets: 202087_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340470
Ensembl peptide - ENSP00000345344
Ensembl peptide - ENSP00000365061
NCBI entrez gene - 1514     See in Manteia.
OMIM - 116880
RefSeq - NM_145918
RefSeq - XM_017014293
RefSeq - NM_001257971
RefSeq - NM_001257972
RefSeq - NM_001257973
RefSeq - NM_001912
RefSeq - XM_005251716
RefSeq - XM_011518263
RefSeq Peptide - NP_001244902
RefSeq Peptide - NP_001903
RefSeq Peptide - NP_666023
RefSeq Peptide - NP_001244900
RefSeq Peptide - NP_001244901
swissprot - A0A024R276
swissprot - P07711
swissprot - Q5T8F0
Ensembl - ENSG00000135047
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctslbENSDARG00000039173Danio rerio
 ctslbENSDARG00000074306Danio rerio
 ctsllENSDARG00000011701Danio rerio
 MGC174155ENSDARG00000095072Danio rerio
 si:dkey-239j18.2ENSDARG00000095254Danio rerio
 si:dkey-239j18.3ENSDARG00000089806Danio rerio
 si:dkey-269i1.4ENSDARG00000095744Danio rerio
 si:dkey-269i1.4ENSDARG00000100833Danio rerio
 si:dkey-26g8.4ENSDARG00000087651Danio rerio
 si:dkey-26g8.5ENSDARG00000089750Danio rerio
 zgc:174153ENSDARG00000079376Danio rerio
 zgc:174154ENSDARG00000075527Danio rerio
 zgc:174855ENSDARG00000094559Danio rerio
 CTSVENSGALG00000012610Gallus gallus
 BC051665ENSMUSG00000042243Mus musculus
 CT030254.2ENSMUSG00000114904Mus musculus
 Cts3ENSMUSG00000074870Mus musculus
 Cts6ENSMUSG00000021441Mus musculus
 Cts7ENSMUSG00000021440Mus musculus
 Cts8ENSMUSG00000057446Mus musculus
 CtsjENSMUSG00000055298Mus musculus
 Ctsll3ENSMUSG00000056728Mus musculus
 CtsmENSMUSG00000074871Mus musculus
 CtsqENSMUSG00000021439Mus musculus
 CtsrENSMUSG00000055679Mus musculus
 Q80UB0ENSMUSG00000050345Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTSV / O60911 / cathepsin VENSG0000013694377
CTSK / P43235 / cathepsin KENSG0000014338750
CTSS / P25774 / cathepsin SENSG0000016313148
CTSH / P09668 / cathepsin HENSG0000010381138
CTSF / Q9UBX1 / cathepsin FENSG0000017408035
CTSW / P56202 / cathepsin WENSG0000017254330


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0019882 antigen processing and presentation TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030574 collagen catabolic process IDA
 biological_processGO:0045616 regulation of keratinocyte differentiation TAS
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0071888 macrophage apoptotic process NAS
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0036021 endolysosome lumen TAS
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001968 fibronectin binding IPI
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0043394 proteoglycan binding IPI
 molecular_functionGO:0097655 serpin family protein binding IPI


Pathways (from Reactome)
Pathway description
Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197641 Q9UIV8 / SERPINB13 / serpin family B member 13  / complex / reaction
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / reaction
 ENSG00000135047 CTSL / P07711 / cathepsin L  / complex






 

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