ENSMUSG00000050345


Mus musculus

Features
Gene ID: ENSMUSG00000050345
  
Biological name :4930486L24Rik
  
Synonyms : 4930486L24Rik / Q80UB0 / Testin-2 Testin-1
  
Possible biological names infered from orthology : cathepsin L / CTSL / P07711
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B2
Gene start: 60842612
Gene end: 60864475
  
Corresponding Affymetrix probe sets: 10409857 (MoGene1.0st)   1430051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089157
NCBI entrez gene - 214639     See in Manteia.
MGI - MGI:1922258
RefSeq - NM_178098
RefSeq Peptide - NP_835199
swissprot - Q80UB0
Ensembl - ENSMUSG00000050345
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctslbENSDARG00000039173Danio rerio
 ctslbENSDARG00000074306Danio rerio
 ctsllENSDARG00000011701Danio rerio
 MGC174155ENSDARG00000095072Danio rerio
 si:dkey-239j18.2ENSDARG00000095254Danio rerio
 si:dkey-239j18.3ENSDARG00000089806Danio rerio
 si:dkey-269i1.4ENSDARG00000095744Danio rerio
 si:dkey-269i1.4ENSDARG00000100833Danio rerio
 si:dkey-26g8.4ENSDARG00000087651Danio rerio
 si:dkey-26g8.5ENSDARG00000089750Danio rerio
 zgc:174153ENSDARG00000079376Danio rerio
 zgc:174154ENSDARG00000075527Danio rerio
 zgc:174855ENSDARG00000094559Danio rerio
 CTSVENSGALG00000012610Gallus gallus
 CTSLENSG00000135047Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsll3 / cathepsin L-like 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005672863
BC051665 / cDNA sequence BC051665 / CTSL* / P07711* / cathepsin L*ENSMUSG0000004224362
Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*ENSMUSG0000002147759
Ctsj / Q9R014 / cathepsin J / CTSL* / P07711* / cathepsin L*ENSMUSG0000005529855
Cts6 / cathepsin 6 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144154
Cts8 / Q9JI81 / cathepsin 8 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005744653
Ctsm / cathepsin M / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487153
Cts3 / cathepsin 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487051
Ctsq / cathepsin Q / CTSL* / P07711* / cathepsin L*ENSMUSG0000002143951
Ctsr / Q9JIA9 / cathepsin R / CTSL* / P07711* / cathepsin L*ENSMUSG0000005567951
Ctsk / P55097 / cathepsin K / P43235*ENSMUSG0000002811147
Cts7 / Q91ZF2 / cathepsin 7 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144047
Ctss / O70370 / cathepsin S / P25774*ENSMUSG0000003864245
Ctsh / P49935 / cathepsin H / P09668*ENSMUSG0000003235935
Ctsf / Q9R013 / cathepsin F / Q9UBX1*ENSMUSG0000008328234
Ctsw / P56203 / cathepsin W / P56202*ENSMUSG0000002491029
CT030254.2 / CTSL* / P07711* / cathepsin L*ENSMUSG0000011490417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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