ENSMUSG00000083282


Mus musculus

Features
Gene ID: ENSMUSG00000083282
  
Biological name :Ctsf
  
Synonyms : cathepsin F / Ctsf / Q9R013
  
Possible biological names infered from orthology : Q9UBX1
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 4855129
Gene end: 4860912
  
Corresponding Affymetrix probe sets: 10460468 (MoGene1.0st)   1449794_x_at (Mouse Genome 430 2.0 Array)   1451019_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112481
NCBI entrez gene - 56464     See in Manteia.
MGI - MGI:1861434
RefSeq - NM_019861
RefSeq Peptide - NP_063914
swissprot - Q9R013
Ensembl - ENSMUSG00000083282
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctsfENSDARG00000063095Danio rerio
 CTSFENSG00000174080Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsw / P56203 / cathepsin W / P56202*ENSMUSG0000002491029
Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*ENSMUSG0000002147727
Ctsj / Q9R014 / cathepsin J / CTSL* / P07711* / cathepsin L*ENSMUSG0000005529826
Cts6 / cathepsin 6 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144125
BC051665 / cDNA sequence BC051665 / CTSL* / P07711* / cathepsin L*ENSMUSG0000004224325
Cts7 / Q91ZF2 / cathepsin 7 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144025
Cts8 / Q9JI81 / cathepsin 8 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005744624
Ctsm / cathepsin M / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487124
Ctsll3 / cathepsin L-like 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005672824
Ctsh / P49935 / cathepsin H / P09668*ENSMUSG0000003235924
Q80UB0 / 4930486L24Rik / Testin-2 Testin-1 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005034524
Ctsr / Q9JIA9 / cathepsin R / CTSL* / P07711* / cathepsin L*ENSMUSG0000005567923
Cts3 / cathepsin 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487023
Ctsq / cathepsin Q / CTSL* / P07711* / cathepsin L*ENSMUSG0000002143923
Ctsk / P55097 / cathepsin K / P43235*ENSMUSG0000002811123
Ctss / O70370 / cathepsin S / P25774*ENSMUSG0000003864221
CT030254.2 / CTSL* / P07711* / cathepsin L*ENSMUSG000001149048


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btctm1Dcl/Btctm1Dcl,Hbegftm1Dcl/Hbegftm1Dcl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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