ENSMUSG00000038642


Mus musculus

Features
Gene ID: ENSMUSG00000038642
  
Biological name :Ctss
  
Synonyms : cathepsin S / Ctss / O70370
  
Possible biological names infered from orthology : P25774
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 95526786
Gene end: 95556403
  
Corresponding Affymetrix probe sets: 10494271 (MoGene1.0st)   1448591_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015667
Ensembl peptide - ENSMUSP00000112006
NCBI entrez gene - 13040     See in Manteia.
MGI - MGI:107341
RefSeq - NM_001267695
RefSeq - NM_021281
RefSeq Peptide - NP_001254624
RefSeq Peptide - NP_067256
swissprot - O70370
swissprot - F6WR04
Ensembl - ENSMUSG00000038642
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctss2.1ENSDARG00000074656Danio rerio
 ctss2.2ENSDARG00000013771Danio rerio
 CTSSENSGALG00000000775Gallus gallus
 CTSSENSG00000163131Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctsk / P55097 / cathepsin K / P43235*ENSMUSG0000002811152
Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*ENSMUSG0000002147748
Ctsll3 / cathepsin L-like 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005672847
Ctsj / Q9R014 / cathepsin J / CTSL* / P07711* / cathepsin L*ENSMUSG0000005529845
BC051665 / cDNA sequence BC051665 / CTSL* / P07711* / cathepsin L*ENSMUSG0000004224345
Cts6 / cathepsin 6 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144144
Ctsr / Q9JIA9 / cathepsin R / CTSL* / P07711* / cathepsin L*ENSMUSG0000005567944
Q80UB0 / 4930486L24Rik / Testin-2 Testin-1 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005034544
Cts8 / Q9JI81 / cathepsin 8 / CTSL* / P07711* / cathepsin L*ENSMUSG0000005744643
Ctsq / cathepsin Q / CTSL* / P07711* / cathepsin L*ENSMUSG0000002143943
Ctsm / cathepsin M / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487142
Cts7 / Q91ZF2 / cathepsin 7 / CTSL* / P07711* / cathepsin L*ENSMUSG0000002144040
Cts3 / cathepsin 3 / CTSL* / P07711* / cathepsin L*ENSMUSG0000007487038
Ctsh / P49935 / cathepsin H / P09668*ENSMUSG0000003235935
Ctsf / Q9R013 / cathepsin F / Q9UBX1*ENSMUSG0000008328229
Ctsw / P56203 / cathepsin W / P56202*ENSMUSG0000002491026
CT030254.2 / CTSL* / P07711* / cathepsin L*ENSMUSG0000011490416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site
 IPR025661  Cysteine peptidase, asparagine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006955 immune response IBA
 biological_processGO:0010447 response to acidic pH ISO
 biological_processGO:0016485 protein processing ISO
 biological_processGO:0019882 antigen processing and presentation IBA
 biological_processGO:0030574 collagen catabolic process ISO
 biological_processGO:0034769 basement membrane disassembly IMP
 biological_processGO:0048002 antigen processing and presentation of peptide antigen ISO
 biological_processGO:0050729 positive regulation of inflammatory response IGI
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IMP
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:2001259 positive regulation of cation channel activity IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031905 early endosome lumen TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0001968 fibronectin binding ISO
 molecular_functionGO:0004197 cysteine-type endopeptidase activity EXP
 molecular_functionGO:0005518 collagen binding ISO
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043236 laminin binding ISO
 molecular_functionGO:0043394 proteoglycan binding ISO


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Airetm1Pltn/Airetm1Pltn
Genetic Background: B6.129S4-Airetm1Pltn

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ctsstm1Eae/Ctss+
Genetic Background: NOD.D1-Ctsstm1Eae

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0002453 abnormal B lymphocyte antigen presentation "impairment in the ability of B lymphocyte to process and/or present antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Ctsstm1Hap Ldlrtm1Her

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Ctsstm1Hap Ldlrtm1Her

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

Allelic Composition: Ctsstm1Eae/Ctss+
Genetic Background: NOD.D1-Ctsstm1Eae

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2

 MP:0004824 decreased susceptibility to experimental autoimmune myasthenia gravis "reduced likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Ctsstm1Hap Ldlrtm1Her

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129S-Ctsstm1Hap Ldlrtm1Her

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Ctsstm1Hap/Ctsstm1Hap,Dmdmdx/Dmdmdx
Genetic Background: involves: 129S2/SvPas * C57BL/10ScSn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction






 

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