ENSMUSG00000024610


Mus musculus

Features
Gene ID: ENSMUSG00000024610
  
Biological name :Cd74
  
Synonyms : Cd74 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04441
  
Possible biological names infered from orthology : CD74 molecule / P04233
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 60803848
Gene end: 60812646
  
Corresponding Affymetrix probe sets: 10456005 (MoGene1.0st)   1425519_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057836
Ensembl peptide - ENSMUSP00000095171
Ensembl peptide - ENSMUSP00000126688
NCBI entrez gene - 16149     See in Manteia.
MGI - MGI:96534
RefSeq - NM_010545
RefSeq - NM_001042605
RefSeq Peptide - NP_001036070
RefSeq Peptide - NP_034675
swissprot - P04441
swissprot - Q3U4Q8
swissprot - Q545Y5
Ensembl - ENSMUSG00000024610
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd74aENSDARG00000009087Danio rerio
 CD74ENSGALG00000004594Gallus gallus
 CD74ENSG00000019582Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR011988  MHC class II-associated invariant chain, trimerisation
 IPR015386  MHC class II-associated invariant chain/CLIP, MHC II-interacting
 IPR022339  MHC class II-associated invariant chain
 IPR036613  MHC class II-associated invariant chain, trimerisation domain superfamily
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IDA
 biological_processGO:0002792 negative regulation of peptide secretion IEA
 biological_processGO:0002821 positive regulation of adaptive immune response NAS
 biological_processGO:0002830 positive regulation of type 2 immune response IMP
 biological_processGO:0002906 negative regulation of mature B cell apoptotic process IMP
 biological_processGO:0006886 intracellular protein transport IMP
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IMP
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0035691 macrophage migration inhibitory factor signaling pathway IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0045089 positive regulation of innate immune response IC
 biological_processGO:0045581 negative regulation of T cell differentiation IMP
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0045657 positive regulation of monocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IMP
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IDA
 biological_processGO:0070206 protein trimerization IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005771 multivesicular body IDA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0035692 macrophage migration inhibitory factor receptor complex IDA
 cellular_componentGO:0035693 NOS2-CD74 complex IDA
 cellular_componentGO:0042613 MHC class II protein complex IDA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004896 cytokine receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0023026 MHC class II protein complex binding IEA
 molecular_functionGO:0035718 macrophage migration inhibitory factor binding IEA
 molecular_functionGO:0042289 MHC class II protein binding IPI
 molecular_functionGO:0042609 CD4 receptor binding IEA
 molecular_functionGO:0042658 MHC class II protein binding, via antigen binding groove IEA
 molecular_functionGO:0044183 protein binding involved in protein folding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IPI


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Miftm2Gfr/Miftm2Gfr
Genetic Background: C57BL/6-Miftm2Gfr

 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Miftm2Gfr/Miftm2Gfr
Genetic Background: C57BL/6-Miftm2Gfr

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/cAn

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/cAn

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/cAn

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd1d1tm1.1Boes/Cd1d1tm1.1Boes,Cd74tm1Doi/Cd74tm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd74tm2Liz/Cd74tm2Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: B6.129-Sppl2atm1Basc Cd74tm1Liz

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz/J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm1Dow/Runx1tm1Dow
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005041 abnormal antigen presentation via MHC class II "anomaly in the process by which peptide, bound to major histocomptability complex class II, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm2Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/cAn

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74*)1Ayr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: H2-DMatm1Luc/H2-DMatm1Luc,Cd74tm1Doi/Cd74tm1Doi
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0005043 defective assembly of class II molecules "impaired production of major histocompatibility complex class II molecules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm2Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1.1Rdp/Stk11+,Taglntm1(cre/ERT2)Feil/Tagln+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: B6.129S-Cd74tm1Liz

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/cAn

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Liz/H2-DMatm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74)AR194Ayr/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,H2-DMatm1Luc/H2-DMatm1Luc,Tg(CD74*)1Ayr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Cd74tm1Eae/Cd74tm1Eae
Genetic Background: involves: 129S2/SvPas

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd74tm1Doi/Cd74tm1Doi,H2-DMatm1Doi/H2-DMatm1Doi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz,Sppl2atm1Basc/Sppl2atm1Basc
Genetic Background: B6.129-Sppl2atm1Basc Cd74tm1Liz

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edardl-J/Edartm1.1Bamo
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * FVB/N

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/cAn

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * BALB/c * C57BL

Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cd74tm1Liz/Cd74tm1Liz
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Cd74tm3Liz/Cd74tm3Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cd74tm2Liz/Cd74tm2Liz
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: C.Cg-Prf1tm1Sdz Ifngtm1Ts

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013657 abnormal blood cell morphology "any structural anomaly of cells found in the blood" [CL:0000081]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0013705 decreased megakaryocyte-erythroid progenitor cell number "reduced number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / reaction / complex
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex / reaction
 ENSMUSG00000003033 Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*  / complex
 ENSMUSG00000003309 Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*  / complex
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSMUSG00000009090 Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*  / complex
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / reaction / complex
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / reaction / complex
 ENSMUSG00000038642 Ctss / O70370 / cathepsin S / P25774*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex / reaction
 ENSMUSG00000021190 Lgmn / O89017 / legumain / Q99538*  / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / reaction / complex
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSMUSG00000033307 Mif / P34884 / macrophage migration inhibitory factor (glycosylation-inhibiting factor) / P14174* / macrophage migration inhibitory factor*  / reaction / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction / complex
 ENSMUSG00000031731 Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*  / complex
 ENSMUSG00000031367 Ap1s2 / Q9DB50 / AP-1 complex subunit sigma-2 / P56377* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / reaction / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / reaction / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / complex / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / reaction / complex
 ENSMUSG00000041538 H2-Ob / histocompatibility 2, O region beta locus / P13765* / HLA-DOB* / major histocompatibility complex, class II, DO beta*  / reaction
 ENSMUSG00000037649 H2-DMa / histocompatibility 2, class II, locus DMa / P28067* / HLA-DMA* / major histocompatibility complex, class II, DM alpha*  / reaction
 ENSMUSG00000079547 H2-DMb1 / histocompatibility 2, class II, locus Mb1 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / reaction
 ENSMUSG00000024334 H2-Oa / major histocompatibility complex, class II, DO alpha / P06340* / HLA-DOA*  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex / reaction
 ENSMUSG00000037548 H2-DMb2 / histocompatibility 2, class II, locus Mb2 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / reaction
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000004849 Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*  / complex
 ENSMUSG00000054702 Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex






 

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