ENSMUSG00000021190


Mus musculus

Features
Gene ID: ENSMUSG00000021190
  
Biological name :Lgmn
  
Synonyms : legumain / Lgmn / O89017
  
Possible biological names infered from orthology : Q99538
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 102394084
Gene end: 102439813
  
Corresponding Affymetrix probe sets: 10402268 (MoGene1.0st)   1448883_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105647
Ensembl peptide - ENSMUSP00000021607
NCBI entrez gene - 19141     See in Manteia.
MGI - MGI:1330838
RefSeq - NM_011175
RefSeq - XM_017314995
RefSeq Peptide - NP_035305
swissprot - A2RTI3
swissprot - O89017
Ensembl - ENSMUSG00000021190
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgmnENSDARG00000039150Danio rerio
 LGMNENSGALG00000010811Gallus gallus
 LGMNENSG00000100600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pigk / Q9CXY9 / phosphatidylinositol glycan anchor biosynthesis, class K / Q92643*ENSMUSG0000003904719


Protein motifs (from Interpro)
Interpro ID Name
 IPR001096  Peptidase C13, legumain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0006508 proteolysis IMP
 biological_processGO:0006624 vacuolar protein processing IBA
 biological_processGO:0010447 response to acidic pH IMP
 biological_processGO:0032801 receptor catabolic process IMP
 biological_processGO:0040015 negative regulation of multicellular organism growth IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IMP
 biological_processGO:1901185 negative regulation of ERBB signaling pathway IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Vitamin D (calciferol) metabolism
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,X/Tg(Tyr-HRAS)60Lc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0005060 accumulation of giant lysosomes in kidney/renal tubule cells "buildup of contents in lysosomes in cells of the kidney tubules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5590]
Show

Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,X/Tg(Tyr-HRAS)60Lc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Rb1tm2.1Brn/Rb1tm2.1Brn
Genetic Background: Not Specified

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,X/Tg(Tyr-HRAS)60Lc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Crygenz/Cryge+
Genetic Background: involves: 101 * C3H

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0011379 abnormal kidney outer medulla outer stripe morphology "any structural anomaly of the region of the kidney outer medulla that lies just below the cortex; the proximal straight tubules are present in this region" [MP:0072058]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0011425 abnormal kidney interstitium morphology "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Lgmntm1Cptr/Lgmntm1Cptr
Genetic Background: B6.129S6-Lgmntm1Cptr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction






 

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